FB2024_03 , released June 25, 2024
Allele: Dmel\eIF4G2nc32
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General Information
Symbol
Dmel\eIF4G2nc32
Species
D. melanogaster
Name
FlyBase ID
FBal0012548
Feature type
allele
Associated gene
Dmel\eIF4G2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Fuller, 1986)
Progenitor genotype
Cytology
Description

Amino acid replacement: M1467K.

(Baker and Fuller, 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:23,811,996..23,811,996 [-]
Nucleotide change:

T23811996A

Amino acid change:

M1506K | eIF4G2-PA; M1506K | eIF4G2-PC

Reported amino acid change:

M1467K

Comment:

The reported amino acid location is based on an isoform with an intron that removes 39 aa from the first exon of RA.

(Baker and Fuller, 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous males do not undergo meiosis and show no recognisable meiotic or postmeiotic stages of spermatid differentiation. The testes contain cells in the gonial stage, cysts of primary spermatocytes and cysts of aberrant cells in a terminal stage that may represent degenerating primary spermatocytes.

      (Fuller, 1986)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      eIF4G2nc32 is an enhancer of phenotype of βTub85Dunspecified

      (Fuller, 1986)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Fails to complement class I alleles at the βTub85D locus. Meiosis and spermatid differentiation occur in the sterile transheterozygotes.

      (Fuller, 1986)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a mutation that fails to complement class I alleles at the βTub85D locus (either βTub85D3 or βTub85DDrv1) but does not map to the βTub85D locus.

      (Fuller, 1986)
      Comments
      Comments

      Adult homozygous males show no βTub85D synthesis.

      (Fuller, 1986)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      eIF4G2nc32
      (Baker and Fuller, 2007)
      ms(3)nc321
      nc32
      (Fuller, 1986)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)