FB2024_03 , released June 25, 2024
Allele: Dmel\mus101K451
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General Information
Symbol
Dmel\mus101K451
Species
D. melanogaster
Name
FlyBase ID
FBal0012593
Feature type
allele
Associated gene
Dmel\mus101
Associated Insertion(s)
Carried in Construct
Also Known As
fs(1)K451
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Komitopoulou et al., 1988)
Progenitor genotype
Cytology
Description

Amino acid replacement: V675D.

(Kondo and Perrimon, 2011)

Carries a missense mutation (V675D) in an evolutionarily conserved residue in the N-terminal fifth "BRCA1 C-terminal" (BRCT) domain of mus101.

(Kondo and Perrimon, 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:13,724,377..13,724,377 [+]
Nucleotide change:

T13724377A

Amino acid change:

V675D | mus101-PA

Reported amino acid change:

V675D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kondo and Perrimon, 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Similarly to wild-type third-instar larvae, X-ray irradiation of mus101K451 mutants induces cell cycle arrest in wing imaginal disc cells.

      (Kondo and Perrimon, 2011)

      Mutants are sensitive to MMS.

      (Yamamoto et al., 2000)

      Morphological defects: substantial underproduction and disruption of the endochorion, correlated with the underproduction of 6 major chorion protein gene products: Cp15, Cp16, Cp18, Cp19, Cp36 and Cp38.

      (Komitopoulou et al., 1988)

      females produce morphologically abnormal eggs female-sterile Reduced viability, especially of females; abnormalities of posterior legs, also especially in females. fs(1)K451/Df(1)g does not survive. Homozygous females produce eggs with short thin dorsal appendages and ultrastructurally defective chorions. All major chorion proteins underproduced owing to failure of chorion protein gene amplification. Cp genes on the third chromosome more severely affected than those on the X (Orr, Komitopoulou and Kafatos, 1984). In mosaic experiments fs(1)K451 behaves as a locus required in both somatic and germinal tissues (Perrimon and Gans, 1983).

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      mus101K451 is rescued by mus101+t9

      (Yamamoto et al., 2000)
      Not rescued by

      mus101K451 is not rescued by mus101tB10

      (Yamamoto et al., 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Ovaries derived from homozygous females show reduced incorporation of BrdU compared to wild-type, and labeling is mosaic in intensity among the follicle cells.

      (Calvi et al., 1998)

      Complements: l(1)dd4xr16

      (Barbosa et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fs(1)K451
      (Calvi et al., 1998, Komitopoulou et al., 1988, Perrimon et al., 1986, Perrimon and Gans, 1983)
      mus101K451
      (Kondo and Perrimon, 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)