FB2024_03 , released June 25, 2024
Allele: Dmel\ninaD1
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General Information
Symbol
Dmel\ninaD1
Species
D. melanogaster
Name
FlyBase ID
FBal0013001
Feature type
allele
Associated gene
Dmel\ninaD
Associated Insertion(s)
Carried in Construct
Also Known As
ninaDP245
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: W71term.

(Kiefer et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:18,081,935..18,081,935 [+]
Nucleotide change:

G18081935A

Amino acid change:

W71term | ninaD-PA; W71term | ninaD-PB

Reported amino acid change:

W71term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Kiefer et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ninaD1 homozygous adults have highly reduced carotenoid levels compared with wild-type flies, but have otherwise normal lipid content.

      (Kiefer et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      ninaD1 is a suppressor of abnormal neuroanatomy | adult stage phenotype of ninaE17

      (Voolstra et al., 2010)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ninaD1 is a suppressor of rhabdomere phenotype of ninaE17

      (Voolstra et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The degeneration of the rhabdomeres that is seen in 3 day old ninaE17 adults is suppressed if they are doubly mutant with ninaD1.

      (Voolstra et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      ninaD1 is partially rescued by ninaDUAS.cKa/Scer\GAL4hs.PB

      (Kiefer et al., 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ninaD1
      (Huang and Ryoo, 2021, Leung et al., 2020, Li et al., 2020, Katana et al., 2019)
      ninaDP245
      (Katana et al., 2019, Voolstra et al., 2010, Kiefer et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)