FB2024_03 , released June 25, 2024
Allele: Dmel\nonA5
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General Information
Symbol
Dmel\nonA5
Species
D. melanogaster
Name
FlyBase ID
FBal0013087
Feature type
allele
Associated gene
Dmel\nonA
Associated Insertion(s)
Carried in Construct
Also Known As
nonAH2
Key Links
Genomic Maps

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Krejci et al., 1994, Stanewsky et al., 1993)

    loss of function allele

    (Rendahl and Hall, 1996)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: G4596A. Amino acid replacement: G463R. Mutation is just outside the second RRM repeat.

    (Rendahl et al., 1996)

    Point mutation in or close to the second putative RNP-CN RNA binding domain.

    (Rendahl and Hall, 1993)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:16,364,387..16,364,387 [+]
    Nucleotide change:

    G16364387A

    Reported nucleotide change:

    G4596A

    Amino acid change:

    G463R | nonA-PA; G463R | nonA-PB; G463R | nonA-PC; G463R | nonA-PD

    Reported amino acid change:

    G463R

    (Rendahl et al., 1996)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Optomotor blind and wild-type courtship song.

        (Rendahl and Hall, 1993)

        Flying optomotor tests reveal largely reduced optomotor responses to progressive stimulation.

        (Stanewsky et al., 1993)

        nonA5/nonA9 males produce normal courtship songs. Males sing normally.

        (Kulkarni et al., 1988)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        nonA5 is partially rescued by nonAstopII

        (Jones and Rubin, 1990)

        nonA5 is partially rescued by nonA+t11

        (Jones and Rubin, 1990)

        nonA5 is partially rescued by nonA+t16

        (Jones and Rubin, 1990)
        Not rescued by

        nonA5 is not rescued by nonAstopI

        (Jones and Rubin, 1990)

        nonA5 is not rescued by nonAΔ2bp

        (Jones and Rubin, 1990)
        Comments

        Visual defects can be rescued by P element mediated transformation of nonA+.

        (Rendahl et al., 1992)

        Mutant phenotype can be completely rescued by a construct carrying wild-type nonA.

        (Jones and Rubin, 1990)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Heisenberg.

        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        References (10)