FB2024_03 , released June 25, 2024
Allele: Dmel\nwB
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General Information
Symbol
Dmel\nwB
Species
D. melanogaster
Name
Blade
FlyBase ID
FBal0013191
Feature type
allele
Associated gene
Dmel\nw
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Craymer, 1980)
Progenitor genotype
Cytology
Description

A 3 amino acid deletion (ΔCAA) of the signal peptide cleavage site of nw (residues 15-17).

(Ray et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:17,502,951..17,502,959 [+]
Comment:

Deletion of 3 amino acids (CAA) in the signal sequence.

(Ray et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The wings of nwB mutant heterozygotes are mildly tapered distally.

      (Ray et al., 2015)

      Wings of heterozygotes are long and narrow. Female abdomen fails to swell with eggs.

      (Craymer, 1980)

      Wings of nwB/+ long and narrow; variable but does not overlap wild type. Female fertility reduced. Homozygote and nwB/nw2 heterozygote lethal. RK2.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      nwB has visible | dominant phenotype, enhanceable by dpy[+]/dpyolvR

      (Ray et al., 2015)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      nwB has wing phenotype, enhanceable by dpy[+]/dpyolvR

      (Ray et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      dpyolvR enhances the wing phenotypes seen in nwB heterozygotes alone. A spectrum of phenotypes is seen, ranging from a sharply tapered wing blade to complete retraction of the wing blade.

      (Ray et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      nwKG02048

      (Ray et al., 2015)

      nwG18887

      (Ray et al., 2015)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (5)
      Notes on Origin
      Discoverer

      P.H. Lewis, 1947.

      (Craymer, 1980)
      Comments
      Comments

      Individuals display elevated levels of Gpo gene product activity.

      (Davis and MacIntyre, 1988)

      "X ray" was stated as tentative.

      (Craymer, 1980)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      nwB
      (Tanaka et al., 2023, Ray et al., 2015)
      Name Synonyms
      Blade
      (Craymer, 1980)
      Secondary FlyBase IDs
        References (4)