FB2024_03 , released June 25, 2024
Allele: Dmel\ort6
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General Information
Symbol
Dmel\ort6
Species
D. melanogaster
Name
FlyBase ID
FBal0013289
Feature type
allele
Associated gene
Dmel\ort
Associated Insertion(s)
Carried in Construct
Also Known As
ortP306
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Deletion of 8 nucleotides (-276 to -269 relative to the proposed translation start site).

    (Gengs et al., 2002)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    3R:19,659,819..19,659,826 [+]
    Comment:

    8 bp deletion in the 5'UTR of the ort transcript.

    (Gengs et al., 2002)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Compared to controls, ort4/ort6 and ort1/ort6 mutants exhibit weaker phototaxis towards UV light.

        (Gao et al., 2008)

        The temperature preference profile of ort6 homozygous adults is abnormal. There is a broader spread of temperature preferences with a significantly with fewer flies choosing the wild-type majority preference of 24-25'C and an increased preference for lower temperatures. Locomotor activity levels in these animals appear to be normal.

        (Hong et al., 2006)

        Mutants lack the on/off transients of the electroretinogram. Laminar L1/L2 neurons still show robust histamine-activated currents, but much higher concentrations of histamine are required, with the EC500 shifted to approximately 10 fold higher concentrations than normal.

        (Gengs et al., 2002)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        ort1/ort6 in a HisCl1134, ninaE1 mutant background significantly reduces the phototactic preference for ultraviolet light over green light seen in wild type and control flies.

        Expressing ortScer\UAS.2x.T:Ivir\HA1 in Tm5c neurons in a homozygous ort1, ort1/ort4, ort1/ort6 background (with HisCl1134 and ninaE1) under the control of Scer\GAL4C1a.DBD.ort.T:Zzzz\ZipRREEL and Hsim\VP16AD.VGlut.OK371.T:Zzzz\ZipEERRL,T:SV40\nls2 enhances the preference for green light over UV seen in the mutant flies alone.

        (Karuppudurai et al., 2014)

        HisCl1134,ort1/HisCl1134,ort6 double mutants show weak phototaxis towards green light.

        (Gao et al., 2008)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        ort6 is partially rescued by orths.PG

        (Gengs et al., 2002)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Pak.

        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        References (10)