FB2024_03 , released June 25, 2024
Allele: Dmel\osk3
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General Information
Symbol
Dmel\osk3
Species
D. melanogaster
Name
FlyBase ID
FBal0013305
Feature type
allele
Associated gene
Dmel\osk
Associated Insertion(s)
Carried in Construct
Also Known As
osk88
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: T2345C. Nucleotide substitution: A2352T. Amino acid replacement: N561Y.

(Kim-Ha et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:8,937,169..8,937,169 [+]
Nucleotide change:

A8937169T

Reported nucleotide change:

A2352T

Amino acid change:

N561Y | osk-PA; N423Y | osk-PC; N209Y | osk-PD

Reported amino acid change:

N561Y

(Kim-Ha et al., 1991)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      An increased number of cells undergo TUNEL-positive cell death in the posterior half of osk3/osk6 embryos compared to wild-type embryos. This cell death at the embryonic stage corresponds to missing tissue at the larval stage.

      (Werz et al., 2005)

      Maternal effect phenotype when in trans with a deficiency for osk.

      (Ephrussi et al., 1991)

      Lack posterior body pattern elements and germ cells.

      (Kim-Ha et al., 1991)

      Absence of posterior pole plasm, polar granules and pole cells.

      (Lehmann and Nusslein-Volhard, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of BacA\p35Scer\UAS.P\T.cWa under the control of Scer\GAL4tub significantly reduces the amount of TUNEL-positive cell death in osk3/osk6 embryos.

      (Werz et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Normal localization of osk mRNA.

      (Kim-Ha et al., 1991)

      Strong allele of osk. The abdominal phenotype of osk can be rescued by cytoplasmic transplantation of wild type posterior pole plasm into the abdominal regions of mutant embryos.

      (Lehmann and Nusslein-Volhard, 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (9)