FlyBase Allele Report: Dmel\ovo[svb-1]

General Information

Symbol

Dmel\ovo^svb-1

Species

D. melanogaster

Name

FlyBase ID

FBal0013437

Feature type

allele

Associated gene

Dmel\ovo

Associated Insertion(s)

Carried in Construct

Also Known As

svb¹, svb^YD39

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Morize et al., 1998)

Mutagen

ethyl methanesulfonate

(Garfinkel et al., 1992, Lindsley and Zimm, 1992)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Lindsley and Zimm, 1992, Oliver et al., 1987)

visible | somatic clone

(Delon et al., 2003)

Phenotype Manifest In

adult thorax & microchaeta | somatic clone

(Delon et al., 2003)

denticle | ectopic, with Scer\GAL4^ptc-559.1, ovo^-2b.UAS

(Salles et al., 2002)

denticle | ectopic, with Scer\GAL4^ptc-559.1, ovo^+2b.UAS

(Salles et al., 2002)

embryonic/first instar larval cuticle

(Andrews et al., 2000)

embryonic epidermis

(Payre et al., 1999)

sex comb

(Gergen and Wieschaus, 1985)

sternopleural bristle | male

(Gergen and Wieschaus, 1985)

ventral denticle belt

(Salles et al., 2002, Payre et al., 1999, Gergen and Wieschaus, 1985)

Detailed Description

Statement

Reference

Microchaetae are reduced in size in mutant clones in the thorax.

(Delon et al., 2003)

Mutant embryos have essentially naked cuticle. Expression of ovo^+2b.Scer\UAS under the control of Scer\GAL4^ptc-559.1 in ovo^svb-1 embryos rescues denticle rows 2 and 3 and also induces a stripe of ectopic denticles. Expression of ovo^-2b.Scer\UAS under the control of Scer\GAL4^ptc-559.1 in ovo^svb-1 embryos rescues denticle rows 2 and 3 and also induces a stripe of ectopic denticles.

(Salles et al., 2002)

Hemizygous embryos have a naked cuticle phenotype.

(Andrews et al., 2000)

Fails to complement the Dsec\ovo in D.melanogaster/D.sechellia hybrids.

(Sucena and Stern, 2000)

ovo^svb-1 embryos present almost exclusively naked cuticle, with only sparse atrophied denticles in the posterior-most rows of each belt.

(Payre et al., 1999)

ovo, svb phenotype.

(Garfinkel et al., 1992)

Phenotypic category: ovo^-.

(Lindsley and Zimm, 1992)

Gene activity not detectable. Female germ line has no vitellogenic egg chambers.

(Oliver et al., 1987)

There are many fewer denticles than in the wild-type larva. The remaining denticles are small and have characteristic morphology. They are arranged in "belts", with one belt per abdominal segment. The hairs and unpigmented denticles normally found on the dorsal surface of the larva are almost completely eliminated. Hemizygous males are fertile but show reduced adult viability and slight abnormalities in the sternopleural bristles and sex combs. Homozygous females are poorly fertile.

(Gergen and Wieschaus, 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Has no effect on the eye phenotype produced by activated arm constructs. (either arm^S44Y.GMR or arm^S56F.GMR).

(Freeman and Bienz, 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

ovo^svb-1 is partially rescued by Scer\GAL4^ptc-559.1/ovo^+2b.UAS

(Salles et al., 2002)

ovo^svb-1 is partially rescued by Scer\GAL4^ptc-559.1/ovo^-2b.UAS

(Salles et al., 2002)

Not rescued by

ovo^svb-1 is not rescued by ovo^OW10.0

(Garfinkel et al., 1992)

ovo^svb-1 is not rescued by ovo^S-7.2

(Mevel-Ninio et al., 1991)

Comments

ovo^S-7.2 fails to rescue the svb mutant phenotype.

(Mevel-Ninio et al., 1991)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

ovo^svb-1

svb¹

(Preger-Ben Noon et al., 2018, Menoret et al., 2013, Fernandes et al., 2010, Overton et al., 2007, Chanut-Delalande et al., 2006, Delon et al., 2003, Salles et al., 2002, Freeman and Bienz, 2001, Sucena and Stern, 2000, Payre et al., 1999)

svb^YD390

(Morize et al., 1998)

svb^YD39

(Garfinkel et al., 1992, Mevel-Ninio et al., 1991, Oliver et al., 1987, Hoppe and Greenspan, 1986, Gergen and Wieschaus, 1985)

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections

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