FlyBase Allele Report: Dmel\p[p]

General Information

Symbol

Dmel\p^p

Species

D. melanogaster

Name

peach

FlyBase ID

FBal0013456

Feature type

allele

Associated gene

Dmel\p

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

loss of function allele

(Falcon-Perez et al., 2007)

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

Nucleotides 1946-1948 (ATG), part of codons 649-650 of wild-type p are substituted by TT, resulting in a frameshift. The mutated gene encodes residues 1-648 of p, followed by an unrelated segment of 39 amino acids and an early termination codon.

(Falcon-Perez et al., 2007)

Single base pair deletion within codon Q648, resulting in a frameshift. The resulting truncated protein is predicated to contain 648 amino acids from wild-type p followed by 39 additional amino acids. Also contains a silent base change in the P62 codon and a nucleotide change in the p upstream region (POU sequence CAAAT is changed to CCAAT).

(Syrzycka et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:8,661,624..8,661,624 [-]

Comment:

The deletion of a single base (A) in codon Q648 causes a frameshift and early translation termination 39 aa downstream.

(Syrzycka et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Cheli et al., 2010, Falcon-Perez et al., 2007, Syrzycka et al., 2007, Duncan and Kaufman, 1975)

abnormal eye color (with Df(3R)p25)

(Falcon-Perez et al., 2007, Syrzycka et al., 2007)

abnormal eye color (with p^37B)

(Falcon-Perez et al., 2007)

visible

(Falcon-Perez et al., 2007, Duncan and Kaufman, 1975)

visible (with Df(3R)p25)

(Falcon-Perez et al., 2007)

visible (with p^37B)

(Falcon-Perez et al., 2007)

visible | recessive

Phenotype Manifest In

pigment cell

(Falcon-Perez et al., 2007, Duncan and Kaufman, 1975)

pigment cell (with Df(3R)p25)

(Falcon-Perez et al., 2007)

pigment cell (with p^37B)

(Falcon-Perez et al., 2007)

Detailed Description

Statement

Reference

Mutant flies have reduced red pigment in the eye compared to controls.

(Cheli et al., 2010)

Eye colour: abnormal with reduced levels of red and brown pigment (20 and 15% of wild-type levels respectively).

(Falcon-Perez et al., 2007)

Homozygous and p^p/Df(3R)p25 flies show a reduction in pteridine (red) eye pigment levels compared to controls.

(Syrzycka et al., 2007)

p^p males that are also mutant for mle⁴ show darker eye pigmentation with respect their mle⁴/+ sibs.

(Hiebert and Birchler, 1994)

Eye colour: dull ruby.

(Duncan and Kaufman, 1975)

9% normal red and 15% normal brown pigment.

(Beadle, 1937)

Color autonomous in p^p optic disk allowed to undergo metamorphosis in a wild-type host.

(Beadle and Ephrussi, 1936)

Eye colour: lighter and more orange than p¹.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

p^p has visible phenotype, enhanceable by g²

(Falcon-Perez et al., 2007)

p^p has abnormal eye color phenotype, enhanceable by g²

(Falcon-Perez et al., 2007)

p^p has visible phenotype, enhanceable by or^49h

(Falcon-Perez et al., 2007)

p^p has abnormal eye color phenotype, enhanceable by or^49h

(Falcon-Perez et al., 2007)

p^p has visible phenotype, enhanceable by Rab32^ltd-1

(Falcon-Perez et al., 2007)

p^p has abnormal eye color phenotype, enhanceable by Rab32^ltd-1

(Falcon-Perez et al., 2007)

NOT Enhanced by

Statement

Reference

p^p has abnormal eye color phenotype, non-enhanceable by Blos1^ex2

(Cheli et al., 2010)

NOT suppressed by

Statement

Reference

p^p has abnormal eye color phenotype, non-suppressible by Blos1^ex2

(Cheli et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

p^p has pigment cell phenotype, enhanceable by g²

(Falcon-Perez et al., 2007)

p^p has pigment cell phenotype, enhanceable by or^49h

(Falcon-Perez et al., 2007)

NOT suppressed by

Statement

Reference

p^p has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Additional Comments

Genetic Interactions

Statement

Reference

The reduced red eye pigment phenotype of p^p blos1^ex2 double mutants is indistinguishable from that of p^p single mutants.

(Cheli et al., 2010)

Eye colour: g²; p^p eyes are lighter and have significantly reduced levels of red pigment compared to either single mutant. The brown pigment levels are comparable to those seen in p^p single mutants. or^49h; p^p double mutants also have reduced levels of red pigment but similar levels of brown pigment to p^p single mutants.

Eye colour: car¹; p^p eyes are lighter than either single mutant. The levels of red pigment in the double mutants is comparable to that in car¹ single mutant eyes and the level of brown pigment is comparable to p^p single mutant eyes.

Eye colour: ltd¹; p^p eyes are relatively lighter than those of either single mutants.

(Falcon-Perez et al., 2007)

Eye colour: brownish, with p^p/+, w^bf/+. Eye colour: brownish, with p^p/+, w^h/+.

(Judd, 1955)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

p^p is rescued by p^+t5.9

(Syrzycka et al., 2007)

Comments

Images (2)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (398)

Bloomington

553

p^p

2552

p^p e¹

555

p^p cu¹

1654

p^p by¹

800

Dfd¹ p^p

4042

Brd¹ p^p

1936

Dhod² p^p

572

rn^roe-1 p^p

Kyoto

105977

p^p

106433

p^p by¹

105986

rn^roe-1 p^p

130331

Df(3L)BSC27/TM2, p^p

More stocks available...

Notes on Origin

Discoverer

Bridges, 24th Jan. 1913.

Comments

The p¹, p^p and p^snb alleles have been found to have identical changes in sequence, despite being reported to have arisen independently. It seems more likely that stock contamination, mislabelling, or loss occurred some time during past handling of stocks, rather than the same lesions having occurred independently three times.

(Syrzycka et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

p^p

(Miller et al., 2016, Harumoto et al., 2014, Kuert et al., 2014, Cheli et al., 2010, Falcon-Perez et al., 2007, Syrzycka et al., 2007)

Name Synonyms

peach

(Falcon-Perez et al., 2007)

Secondary FlyBase IDs

References (28)

Report Sections

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