FB2024_03 , released June 25, 2024
Allele: Dmel\psnb
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General Information
Symbol
Dmel\psnb
Species
D. melanogaster
Name
sunburst
FlyBase ID
FBal0013458
Feature type
allele
Associated gene
Dmel\p
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Falcon-Perez et al., 2007)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotides 1946-1948 (ATG), part of codons 649-650 of wild-type p are substituted by TT, resulting in a frameshift. The mutated gene encodes residues 1-648 of p, followed by an unrelated segment of 39 amino acids and an early termination codon.

    (Falcon-Perez et al., 2007)

    Single base pair deletion within codon Q648, resulting in a frameshift. The resulting truncated protein is predicated to contain 648 amino acids from wild-type p followed by 39 additional amino acids. Also contains a silent base change in the P62 codon and a nucleotide change in the p upstream region (POU sequence CAAAT is changed to CCAAT).

    (Syrzycka et al., 2007)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    3R:8,661,624..8,661,624 [-]
    Comment:

    The deletion of a single base (A) in codon Q648 causes a frameshift and early translation termination 39 aa downstream.

    (Syrzycka et al., 2007)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Eye colour: abnormal with reduced levels of red and brown pigment (25 and 20% of wild-type levels respectively).

        (Falcon-Perez et al., 2007)

        psnb/Df(3R)p25 flies show a reduction in pteridine (red) eye pigment levels compared to controls.

        (Syrzycka et al., 2007)

        Malpighian tubule colour: somewhat lighter than normal.

        (Brehme and Demerec, 1942)

        Eye colour: dull ruby with purplish tone. 40% normal red and 33% normal brown pigment.

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        psnb has visible phenotype, enhanceable by Rab32ltd-1

        (Falcon-Perez et al., 2007)

        psnb has abnormal eye color phenotype, enhanceable by Rab32ltd-1

        (Falcon-Perez et al., 2007)
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        psnb has pigment cell phenotype, enhanceable by Rab32ltd-1

        (Falcon-Perez et al., 2007)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Eye colour: ltd1; psnb eyes are lighter and have significantly reduced levels of red pigment compared to either single mutant.

        (Falcon-Perez et al., 2007)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Dobzhansky.

        Comments
        Comments

        Polytene chromosomes show no evidence of a deletion.

        (Silva, 1988)

        The p1, pp and psnb alleles have been found to have identical changes in sequence, despite being reported to have arisen independently. It seems more likely that stock contamination, mislabelling, or loss occurred some time during past handling of stocks, rather than the same lesions having occurred independently three times.

        (Syrzycka et al., 2007)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        psnb
        (Falcon-Perez et al., 2007, Syrzycka et al., 2007)
        Name Synonyms
        sunburst
        (Falcon-Perez et al., 2007, Silva, 1988)
        Secondary FlyBase IDs
          References (6)