FB2024_03 , released June 25, 2024
Allele: Dmel\paralk2
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General Information
Symbol
Dmel\paralk2
Species
D. melanogaster
Name
FlyBase ID
FBal0013481
Feature type
allele
Associated gene
Dmel\para
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Broadie and Bate, 1993)

    loss of function allele

    (Hong and Ganetzky, 1994)
    Mutagen
    Progenitor genotype
    Caused by aberration
    In(1)paralk2
    Cytology
    Description

    break at 20.5-23 kb

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Flies carrying paraJS1 in trans to paralk2 are viable but exhibit paralysis after heat shock.

        (Song and Tanouye, 2007)

        Homozygous embryos generally survive through embryogenesis until hatching.

        (Hong and Ganetzky, 1994)

        Greatly reduced synaptic activity: all bursting activity is absent, both frequency and amplitude of excitatory junction currents (EJCs) are greatly reduced at the embryonic neuromuscular junction (NMJ). Embryos hatch normally at 25oC but fail to hatch at 30oC. Synaptic transmission is dramatically reduced at room temperature and completely blocked at 32oC.

        (Broadie and Bate, 1993)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        In homozygotes postsynaptic GluRIIA expression is unaffected. At 32oC GluRIIA expression is reduced and absent at 34oC.

        (Broadie and Bate, 1993)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        paralK2
        (Song and Tanouye, 2007)
        paralk2
        Name Synonyms
        Secondary FlyBase IDs
          References (4)