paraST76 mutant larvae do not display any resistance to picrotoxin (PTX)-induced seizures.
The seizure threshold following short wavetrains of high-frequency electrical stimuli (0.5ms pulses at 200Hz for 300ms) is increased in mutant flies (65.0 +/- 7.2 V) compared to controls.
The threshold for activation of the giant fiber in mutant animals following single stimulus pulses (0.2ms duration, 0.5Hz) is not significantly different from that of wild type.
The giant fiber following frequency (the maximum stimulation frequency that the giant fiber pathway can reliably follow) is reduced compared to wild type in mutant animals.
Homozygous flies do not show significant resistance to dichloro-diphenyl-trichloro ethane (DDT) compared to wild-type flies.
Viability of double mutant males with mlenap-ts1 is significantly reduced, even at permissive temperatures. Double mutant males at 25oC die at or near eclosion.
Reversible heat induced paralysis.
paraST76 is a suppressor of abnormal neurophysiology phenotype of jusiso6.10
jusiso6.10, paraST76 has abnormal neurophysiology phenotype
jusiso6.10, paraST76 has giant fiber neuron phenotype
paraST76 suppresses the reduced seizure threshold of sdaiso6.10 flies following high-frequency electrical stimuli, raising the seizure threshold to wild-type levels in the double mutant flies.
The threshold for activation of the giant fiber in sdaiso6.10 paraST76 animals following single stimulus pulses (0.2ms duration, 0.5Hz) is not significantly different from that of wild type.
The giant fiber following frequency (the maximum stimulation frequency that the giant fiber pathway can reliably follow) of paraST76 sdaiso6.10 double mutants is reduced compared to either single mutant.
Results from response to cervical stimulation, intracellular recordings of flight muscles and direct excitability of muscle demonstrate the threshold for excitability of a cervical pathway rises at temperatures a few degrees higher than the paralysis temperature while nerve conduction velocity and muscle excitability are still normal.