FlyBase Allele Report: Dmel\Pcl[5]

General Information

Symbol

Dmel\Pcl⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0013612

Feature type

allele

Associated gene

Dmel\Pcl

Associated Insertion(s)

Carried in Construct

Also Known As

Pcl^D5

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl nitrosourea

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Simon et al., 1992, Breen and Duncan, 1986)

Mutagen

ethyl nitrosourea

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Breen and Duncan, 1986)

lethal (with Df(2R)ED3610)

(Kahsai et al., 2016)

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}4

(Mallin et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

Somatic mitotic clones of Pcl⁵ do not induce ovarian defects.

(Narbonne et al., 2004)

Embryos doubly mutant for Psc^Arp.1 and Pcl⁵ show posteriorly directed segmental transformations. There is medial erosion of the ventral setae and ectopic Fell hairs are seen in approximately 60% of cases.

(Adler et al., 1991)

Weak posteriorly directed transformations.

(Breen and Duncan, 1986)

enhances Mcp

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Pcl⁵/Pcl[+] is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, asf1^UAS.cMa

(Moshkin et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Pcl⁵/+ does not suppress the rough eye phenotype due to Scer\GAL4^ey.PH; asf1^Scer\UAS.cMa.

(Moshkin et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

24157

w^*; P{neoFRT}42D Pcl⁵/CyO

Notes on Origin

Discoverer

Breen.

Comments

Ectopic abd-A expression occurs throughout the A-P axis but cellular distribution within each segment is limited. Abd-B shows a graded expression at 9 hours along the A-P axis, more concentrated in the posterior (Jurgens, Nature 316: 153--155, Breen, Dev. Biol. 118: 442--456). By 12 hours the expression is more uniform.

(Simon et al., 1992)

Weak derepression of en expression.

(Moazed and O'Farrell, 1992)

Shows no significant dominant suppression of the nos mutant phenotype.

(Pelegri and Lehmann, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pcl⁵

(Song et al., 2018)

Pcl^D5

(de Ayala Alonso et al., 2007, Halachmi et al., 2007, Narbonne et al., 2004, Atchison et al., 2003, Moshkin et al., 2002, Beuchle et al., 2001, Mollaaghababa et al., 2001, Kehle et al., 1998, Roche and Rio, 1998, Soto et al., 1995, McCall et al., 1994, Pelegri and Lehmann, 1994, Simon et al., 1993, Moazed and O'Farrell, 1992, Adler et al., 1991, Adler et al., 1989, Breen and Duncan, 1986)

Name Synonyms

Secondary FlyBase IDs

References (21)

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