FlyBase Allele Report: Dmel\sc[6]

General Information

Symbol

Dmel\sc⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0015195

Feature type

allele

Associated gene

Dmel\sc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Lindsley and Zimm, 1992)

Progenitor genotype

Caused by aberration

Df(1)sc⁶

Cytology

No inversion.

(Lindsley and Zimm, 1992)

Description

Deletion in the sc regulatory region.

(Gause et al., 1996)

17.4 kb deletion in 7.4 to -10.8 kb.

(Lindsley and Zimm, 1992)

16 kb deletion located 25 kb 3' from the sc transcribed region.

(Cubas et al., 1991)

16kb deletion located 25kb downstream from sc.

(Romani et al., 1989)

Deletion of approximately 17.4kb.

(Campuzano et al., 1985)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Golovnin et al., 1999)

Phenotype Manifest In

anterior notopleural bristle

(Golovnin et al., 1999, Lindsley and Zimm, 1992)

anterior orbital bristle

(Golovnin et al., 1999, Lindsley and Zimm, 1992)

middle orbital bristle

(Lindsley and Zimm, 1992)

ocellar bristle

(Golovnin et al., 1999, Lindsley and Zimm, 1992)

postocellar bristle

(Golovnin et al., 1999, Lindsley and Zimm, 1992)

Detailed Description

Statement

Reference

More than 90% of flies lack the anterior notopleural, postvertical and ocellar bristles. More than 10% of flies lack the anterior orbital bristles. The humeral, presutural, anterior postalar, anterior supraalar, scutellar, posterior postalar and posterior supraalar bristles are present.

(Golovnin et al., 1999)

Slight sc; removes coxals, ocellars, first and second orbitals, postverticals, and anterior notopleurals. Scutellars and sternitals not affected. RK1.

(Lindsley and Zimm, 1992)

Flies lack the ANP macrochaetae, tr2 sensilla trichiodea and at least two of the three sensilla campaniformia on the ANWP. The ANWP and ANP clusters are absent and the APA cluster is reduced. The level of protein in the tegula and PNP clusters is also reduced.

(Cubas et al., 1991)

Absence or strong reduction of a prominent spot located on the notopleural region of the third larval instar wing disc.

(Romani et al., 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

sc⁶ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Additional Comments

Genetic Interactions

Statement

Reference

In female D.simulans/D.melanogaster hybrids heterozygous for sc⁶ the anterior notopleural bristle and the anterior postalar bristle are lost at a very high frequency compared to female D.simulans/D.melanogaster hybrid controls, when grown at 25^oC. There is no increase in bristle loss at 18^oC.

(Skaer and Simpson, 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (2)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type