FB2024_03 , released June 25, 2024
Allele: Dmel\sm1
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General Information
Symbol
Dmel\sm1
Species
D. melanogaster
Name
FlyBase ID
FBal0015720
Feature type
allele
Associated gene
Dmel\sm
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  autosomal recessive intellectual developmental disorder
      modeled by Nab2EP3716
      (Rounds et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      sm3/sm1 flies of both sexes lack almost all bristles on the ventral surface of the abdomen. All acrostichial hairs and microchaetae around the eyes are missing. Aristae are reduced and dorsal macrochaetae, including scutellars, are worn, thinned and sometimes missing. Sternopleural macrochaetae and microchaetae appear normal. Viability is poor and both sexes are sterile.

      (zur Lage et al., 1997)

      Abdomen partially denuded of bristles and shrunken. Wings usually warped and semierect. Acrostichal hairs disarranged. Tendency for erect postscutellars. Male genitalia often disturbed. Anal protuberance of female bent down. Viability 30% wild type. Both sexes entirely sterile. RK2.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      sm[+]/sm1 is an enhancer of visible | dominant phenotype of N55e11

      (Kankel et al., 2007)
      Suppressor of
      Statement
      Reference

      sm[+]/sm1 is a suppressor | partially of visible | adult stage phenotype of Nab2EP3716, Scer\GAL4GMR.PU

      (Rounds et al., 2022)

      sm[+]/sm1 is a suppressor of abnormal eye color phenotype of Nab2EP3716, Scer\GAL4GMR.PU

      (Rounds et al., 2022)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      sm1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Enhancer of
      Statement
      Reference

      sm[+]/sm1 is an enhancer of wing phenotype of N55e11

      (Kankel et al., 2007)
      Suppressor of
      Statement
      Reference

      sm[+]/sm1 is a suppressor | partially of eye phenotype of Nab2EP3716, Scer\GAL4GMR.PU

      (Rounds et al., 2022)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dominantly enhances the Df(1)N-54l9/+ and N55e11/+ wing nicking phenotypes.

      (Kankel et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Bridges, 14th March 1935.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sm1
      (Rounds et al., 2022, Christensen et al., 2009.6.15, Christensen et al., 2009.7.22, Kankel et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)