FB2024_03 , released June 25, 2024
Allele: Dmel\Su(H)12
Open Close
General Information
Symbol
Dmel\Su(H)12
Species
D. melanogaster
Name
FlyBase ID
FBal0016313
Feature type
allele
Associated gene
Dmel\Su(H)
Associated Insertion(s)
P{}Su(H)12
Carried in Construct
Also Known As
MR1, Su(H)MR1
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Morel and Schweisguth, 2000, Schweisguth and Posakony, 1992)
Mutagen
PM hybrid dysgenesis
(Ashburner et al., 1999.10.12, Furukawa et al., 1992)
P-element activity
(Schweisguth and Posakony, 1992)
Progenitor genotype
Associated Insertion(s)
P{}Su(H)12
Cytology
Description

Insertion of a defective P-element at position +65 (transcription start site is position +1).

(Morel and Schweisguth, 2000)

Insertion of a truncated P-element of approximately 2.0kb into Su(H), in the region between -700bp and -500bp (the major transcription initiation site is set as 0).

(Furukawa et al., 1992)

Insertion of a 1.2kb P-element at nucleotide +65, coordinate +12 on the restriction map of the Su(H) region, coordinate 0 is the second chromosome breakpoint of Tp(3;2)AntpCtx.

(Schweisguth and Posakony, 1992)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Su(H)12/Su(H)del47 animals have a rough eye phenotype.

      (Morel and Schweisguth, 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Su(H)[+]/Su(H)12 is a suppressor of visible phenotype of DeltaUAS.cJa, Scer\GAL4l(3)31-1-31-1

      (Jacobsen et al., 1998)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Su(H)[+]/Su(H)12 is a suppressor of presutural bristle & trichogen cell phenotype of DeltaUAS.cJa, Scer\GAL4l(3)31-1-31-1

      (Jacobsen et al., 1998)

      Su(H)[+]/Su(H)12 is a suppressor of anterior notopleural bristle & trichogen cell phenotype of DeltaUAS.cJa, Scer\GAL4l(3)31-1-31-1

      (Jacobsen et al., 1998)

      Su(H)[+]/Su(H)12 is a suppressor of posterior notopleural bristle & trichogen cell phenotype of DeltaUAS.cJa, Scer\GAL4l(3)31-1-31-1

      (Jacobsen et al., 1998)

      Su(H)[+]/Su(H)12 is a suppressor of anterior supraalar bristle & trichogen cell phenotype of DeltaUAS.cJa, Scer\GAL4l(3)31-1-31-1

      (Jacobsen et al., 1998)

      Su(H)[+]/Su(H)12 is a suppressor of anterior postalar bristle & trichogen cell phenotype of DeltaUAS.cJa, Scer\GAL4l(3)31-1-31-1

      (Jacobsen et al., 1998)

      Su(H)[+]/Su(H)12 is a suppressor of posterior postalar bristle & trichogen cell phenotype of DeltaUAS.cJa, Scer\GAL4l(3)31-1-31-1

      (Jacobsen et al., 1998)

      Su(H)[+]/Su(H)12 is a suppressor of posterior dorsocentral bristle & trichogen cell phenotype of DeltaUAS.cJa, Scer\GAL4l(3)31-1-31-1

      (Jacobsen et al., 1998)

      Su(H)[+]/Su(H)12 is a suppressor of anterior scutellar bristle & trichogen cell phenotype of DeltaUAS.cJa, Scer\GAL4l(3)31-1-31-1

      (Jacobsen et al., 1998)

      Su(H)[+]/Su(H)12 is a suppressor of posterior scutellar bristle & trichogen cell phenotype of DeltaUAS.cJa, Scer\GAL4l(3)31-1-31-1

      (Jacobsen et al., 1998)

      Su(H)12 is a suppressor of phenotype of H1

      (Furukawa et al., 1992)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The transformation of the trichogen to a tormogen fate in the notal macrochaetae caused by DlScer\UAS.cJa expressed under the control of Scer\GAL4l(3)31-1-31-1 is dominantly suppressed by Su(H)12.

      (Jacobsen et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Shelton.

      Comments
      Comments

      Transposase induced phenotypic and molecular reversion demonstrates the P-element insertion is responsible for the mutant phenotype.

      (Schweisguth and Posakony, 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      MR1
      (Morel and Schweisguth, 2000, Furukawa et al., 1992)
      Su(H)12
      Su(H)MR1
      (Jacobsen et al., 1998, Schweisguth and Posakony, 1992)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)