FB2024_03 , released June 25, 2024
Allele: Dmel\su(r)1
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General Information
Symbol
Dmel\su(r)1
Species
D. melanogaster
Name
FlyBase ID
FBal0016334
Feature type
allele
Associated gene
Dmel\su(r)
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bahn, 1972)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Rawls, 2006)

Amino acid replacement: G193E.

(Rawls, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:9,199,541..9,199,541 [-]
Nucleotide change:

G9199541A

Reported nucleotide change:

G?A

Amino acid change:

G193E | su(r)-PC

Reported amino acid change:

G193E

Comment:

The reported amino acid change is from Figure 4 of FBrf0192211 and does not agree with the G203E location reported in the text.

(Rawls, 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous males are hypersensitive to 5-fluorouracil compared to control flies.

      (Rawls, 2006)

      Suppresses both the phenotypic effects and the female sterility of all r alleles; also suppresses the r phenocopying and lethal effects of 6-azauracil administration. Little or no dihydrouracil dehydrogenase activity. Thought to interfere with pyrimidine catabolism. Unable to degrade uracil and extremely sensitive to exogenous pyrimidine. Enhances the expression of dp and net and causes b flies to have very black bodies, darker than wild type, especially along the wing veins; forms synthetic lethals in combination with tt and whd.

      (Lindsley and Zimm, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      su(r)1 is a suppressor of visible phenotype of rC

      (Rawls, 2006)
      Other
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      su(r)1 is a suppressor of wing phenotype of rC

      (Rawls, 2006)

      su(r)1 is a suppressor of phenotype of runspecified

      (Bahn, 1972)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      su(r)1, rC; b1 mutants show wild-type freezing responses in 60% of flies and exhibit a delayed response in only 20% of flies.

      (Chaturvedi et al., 2014)

      Suppressor effect on the pyrimidine requiring mutant r is due to a block in the catabolic pathway of pyrimidines.

      (Bahn, 1972)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Su(r)1
      (Chaturvedi et al., 2014)
      su(r)1
      (Müller et al., 2013, Rawls, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)