FB2024_03 , released June 25, 2024
Allele: Dmel\tn1
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General Information
Symbol
Dmel\tn1
Species
D. melanogaster
Name
FlyBase ID
FBal0016900
Feature type
allele
Associated gene
Dmel\tn
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Labeau-Dimenna et al., 2012)

hypomorphic allele - molecular evidence

(Labeau-Dimenna et al., 2012)
Mutagen
spontaneous
(Lindsley and Zimm, 1992)
Progenitor genotype
Cytology
Description

Sequencing of the cDNA for tn in tn1 animals did not reveal any amino acid changes, suggesting that this mutation might affect regulatory regions.

(Labeau-Dimenna et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tn1/Df(2R)Exel6068 pupae are thin and long. Compared to wild type, mutant L3 larval skeletal muscles are narrower, round in cross-section and relatively loose at attachment sites. At higher magnification, mutant muscles show gaps between the myofibrils and the fibres appear unbundled, and there is irregular clustering of nuclei within mutant muscle cells.

      tn1/tnΔA pupae are thin and long.

      tn1/tnΔB pupae are thin and long.

      A large proportion of tn1/Df(2R)Exel6068, tn1/tnΔA or tn1/tnΔB animals die during embryogenesis; either no or very low numbers are lost during larval stages; animals that survive the larval stages die as pupae.

      (Labeau-Dimenna et al., 2012)

      Fully penetrant recessive lethal (no homozygous adults recovered). Hatching occurs late and second/third instar moult is delayed. Third instar larvae are long, thin, and rather slow-moving; histological examination shows abnormal muscle structure. Puparium also long and thin. Pupal development of homozygotes incomplete. Since mutants are unable to perform movements necessary for pupation, they die prior to eclosion.

      (Lindsley and Zimm, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      tnΔA/tn1 has visible | pupal stage phenotype, non-enhanceable by Df(3R)Mlp84BP8/+

      (Labeau-Dimenna et al., 2012)

      tnΔA/tn1 has visible | pupal stage phenotype, non-enhanceable by sls[+]/slsj1D7

      (Labeau-Dimenna et al., 2012)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Df(3R)Mlp84BP8/+ or slsj1D7/+ does not enhance the tn1/tnΔA thin pupae phenotype.

      tn1/+ does not enhance the Df(3R)Mlp84BP8/Df(3R)dsx2M thin pupae phenotype.

      (Labeau-Dimenna et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      l(2)tn
      (Labeau-Dimenna et al., 2012)
      tn1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)