FB2024_03 , released June 25, 2024
Allele: Dmel\trh2
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General Information
Symbol
Dmel\trh2
Species
D. melanogaster
Name
FlyBase ID
FBal0017037
Feature type
allele
Associated gene
Dmel\trh
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: I233N.

(Chung et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:371,067..371,067 [-]
Nucleotide change:

T371067A

Reported nucleotide change:

T?A

Amino acid change:

I233N | trh-PA; I233N | trh-PB; I270N | trh-PC; I233N | trh-PD; I233N | trh-PE; I270N | trh-PF; I233N | trh-PG

Reported amino acid change:

I233N

(Chung et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Single cell class IV dendrite arborisation (da) neuron clones that are homozygous for trh2 do not show defects in the establishment or maintenance of dendritic tiling.

      (Parrish et al., 2007)

      In trh2 homozygous embryos, salivary duct cells fail to invaginate, instead remaining clustered on the surface of the embryo.

      (Haberman et al., 2003)

      Stage 16 trh2 homozygous embryos lack all signs of a tracheal system.

      (Jin et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Tracheal primordia development in trh2 homozygotes is rescued by trhScer\UAS.T:Zzzz\FLAG; Scer\GAL4arm.PS, but not by trhS665A.Scer\UAS.T:Zzzz\FLAG; Scer\GAL4arm.PS.

      (Jin et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      trh2 is rescued by trhUAS.Tag:FLAG/Scer\GAL4arm.PS

      (Jin et al., 2001)
      Not rescued by

      trh2 is not rescued by Scer\GAL4arm.PS/trhS665A.UAS.Tag:FLAG

      (Jin et al., 2001)
      Comments

      Tracheal primordia development in trh2 homozygotes is not rescued by trhS665A.Scer\UAS.T:Zzzz\FLAG; Scer\GAL4arm.PS.

      (Jin et al., 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      trachealess2
      (Okegbe and DiNardo, 2011)
      trh2
      (Lovato et al., 2019, Chung et al., 2011, Morozova et al., 2010, Parrish et al., 2007)
      trh7J83
      (Jin et al., 2001)
      trh7J
      (Tearle and Nusslein-Volhard, 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)