FB2024_03 , released June 25, 2024
Allele: Dmel\vk
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General Information
Symbol
Dmel\vk
Species
D. melanogaster
Name
FlyBase ID
FBal0017793
Feature type
allele
Associated gene
Dmel\v
Associated Insertion(s)
412{}vk
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Lindsley and Zimm, 1992)
Progenitor genotype
Associated Insertion(s)
412{}vk
Cytology
Description

Identical insertion of 7.5kb 412 into first exon of 83 nucleotides.

(Fridell et al., 1990)

Insertion of a 412 element between base pairs 1150 and 1151, 36bp downstream of the major transcription start site, and 21bp upstream of the translation start site. The direction of transcription of the 412 element is opposite to the direction of v transcription.

(Searles et al., 1990)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
X52763
X52764
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      vk flies have only 1.5% of the brown eye-pigment compared to controls.

      (Kuan et al., 2004)

      Not suppressed by Su(vg)B271, Su(vg)E41 or Su(vg)E61.

      (Bazin and Silber, 1992)

      Trace amounts of wild type sized transcripts present in mutants (Searles et al., 1990).

      (Fridell et al., 1990)

      Leaky mutation. Suppressed by su(s) mutations.

      (Searles et al., 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      vk has abnormal eye color phenotype, non-suppressible by su(sable)6/su(sable)UAS.cTa/Scer\GAL4hs.PB

      (Turnage et al., 2000)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      vk has phenotype, suppressible by su(sable)R39

      (Kuan et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      su(s)R39 increases the brown eye-pigment of vk flies from 1.5% to ~50% of that of controls.

      (Kuan et al., 2004)

      The addition of su(s)6, and su(s)Scer\UAS.cTa driven by Scer\GAL4hs.PB does not rescue the vk eye colour phenotype at 25oC.

      (Turnage et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 2 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      vk
      (Kuan et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (14)