FB2024_03 , released June 25, 2024
Allele: Dmel\wis
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General Information
Symbol
Dmel\wis
Species
D. melanogaster
Name
isoxanthopterinless
FlyBase ID
FBal0018267
Feature type
allele
Associated gene
Dmel\w
Associated Insertion(s)
roo{}wis
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Associated Insertion(s)
roo{}wis
Cytology
Description

roo insertion at nucleotide position +4707.

(Larsson et al., 1996)

Insertion into 5' regulatory region.

(Csink et al., 1994)

Insertion of a roo element at +4.7kb.

(Rasmuson-Lestander et al., 1993)

Unknown.

(Birchler and Hiebert, 1989)

probably insert of foreign DNA (R. Jones)

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Repression of wis by z1 is suppressed by Su(z)121.

      (Birve and Rasmuson-Lestander, 1994)

      Eye colour: orange, in z1 wis/Y males. z1 is dominant over z+ in the interaction with wis.

      (Rasmuson-Lestander et al., 1993)

      Eye colour: wild-type. Male has greatly reduced amount of isoxanthopterin in abdomen. Eye colour: variegated, z1 wis male; between z1 and wild-type.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      wis has phenotype, enhanceable by Wowγb

      (Birchler et al., 1994)

      wis has phenotype, enhanceable by Wowγe

      (Birchler et al., 1994)

      wis has phenotype, enhanceable by Wowems1

      (Birchler et al., 1994)

      wis has phenotype, enhanceable by Wowhd1

      (Birchler et al., 1994)
      NOT Enhanced by
      Statement
      Reference

      wis has phenotype, non-enhanceable by z1/Low1

      (Bhadra et al., 1997)

      wis has phenotype, non-enhanceable by In(3)Msu1

      (Csink et al., 1994)

      wis has phenotype, non-enhanceable by In(3)Msu2

      (Csink et al., 1994)

      wis has phenotype, non-enhanceable by Rm62D

      (Csink et al., 1994)

      wis has phenotype, non-enhanceable by Rm62Dem

      (Csink et al., 1994)

      wis has phenotype, non-enhanceable by Rm62E

      (Csink et al., 1994)

      wis has phenotype, non-enhanceable by Rm62F

      (Csink et al., 1994)

      wis has phenotype, non-enhanceable by Rm62H

      (Csink et al., 1994)

      wis has phenotype, non-enhanceable by Rm62K

      (Csink et al., 1994)

      wis has phenotype, non-enhanceable by E(wa)1

      (Birchler and Hiebert, 1989)
      Suppressed by
      Statement
      Reference

      wis has phenotype, suppressible by Mowgamma/z1

      (Bhadra and Birchler, 1996)
      NOT suppressed by
      Statement
      Reference

      wis has phenotype, non-suppressible by z1/Low1

      (Bhadra et al., 1997)

      wis has phenotype, non-suppressible by In(3)Msu1

      (Csink et al., 1994)

      wis has phenotype, non-suppressible by In(3)Msu2

      (Csink et al., 1994)

      wis has phenotype, non-suppressible by Rm62D

      (Csink et al., 1994)

      wis has phenotype, non-suppressible by Rm62Dem

      (Csink et al., 1994)

      wis has phenotype, non-suppressible by Rm62E

      (Csink et al., 1994)

      wis has phenotype, non-suppressible by Rm62F

      (Csink et al., 1994)

      wis has phenotype, non-suppressible by Rm62H

      (Csink et al., 1994)

      wis has phenotype, non-suppressible by Rm62K

      (Csink et al., 1994)
      NOT Suppressor of
      Statement
      Reference

      wis/Low1 is a non-suppressor of phenotype of z1

      (Bhadra et al., 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Eye colour: orange, in z1 wis/Y males.

      (Wu and Howe, 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (13)
      Notes on Origin
      Discoverer

      Rasmuson.

      Comments
      Comments

      Lesion unknown.

      (Bhadra and Birchler, 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      wis
      Name Synonyms
      isoxanthopterinless
      Secondary FlyBase IDs
        References (16)