FB2024_03 , released June 25, 2024
Allele: Dmel\wapl3
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General Information
Symbol
Dmel\wapl3
Species
D. melanogaster
Name
FlyBase ID
FBal0018420
Feature type
allele
Associated gene
Dmel\wapl
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
ethyl methanesulfonate
(Gvozdev et al., 1973)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from germline clones usually arrest prior to blastoderm formation but manage to form small patches of cuticle. Brain cells of mutant larvae show defects in heterochromatin organisation. In metaphase figures, the sister chromatids of the major autosomes and of the X chromosome are aligned parallel to each other, instead of the wild-type X- and V- shaped arrangements. The Y and 4th chromosomes are resolved into two distinct sister chromatids, in contrast to wild type. The sister chromatids of all mutant chromosomes are not completely separated but are instead connected by a thread located in the centromeric region. The mitotic index is normal. The chromocenters of polytene chromosomes appear normal. wapl3/In(1)FM7 females show a significant increase in X chromosome nondisjunction compared to control +/In(1)FM7 females. wapl3 has no effect on meiotic exchange.

      (Verni et al., 2000)

      Lethality occurs during larval and pupal stages. Phenotype of homozygous germ line clones is maternal effect lethal.

      (Perrimon et al., 1985)

      L3 larval/pupal boundary lethal exhibit small disk phenotype; homozygous germ-line clones produce zygotes that arrest in preblastoderm stage.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      wapl3 is rescued by waplGC

      (Verni et al., 2000)
      Not rescued by

      wapl3 is not rescued by wapltB

      (Verni et al., 2000)

      wapl3 is not rescued by wapltA

      (Verni et al., 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Lefevre.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      HC262
      (Perrimon et al., 1985)
      l(1)HC262
      wap3
      (Gvozdev et al., 1973)
      wapl3
      waplHC262
      (Verni et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)