FB2024_03 , released June 25, 2024
Allele: Dmel\IP3K2wy-1
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General Information
Symbol
Dmel\IP3K2wy-1
Species
D. melanogaster
Name
FlyBase ID
FBal0018545
Feature type
allele
Associated gene
Dmel\IP3K2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Dean et al., 2015)
Mutagen
spontaneous
(Lindsley and Zimm, 1992)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Particular wing phenotypes are seen in flies (percentages rounded) of the listed genotypes, (1) being the least severe - (1) a wave-like buckle along the costal vein (distal to its intersection with the subcostal region), (2) an upturn at the most distal margin of the wing, (3) overall shriveled morphology (distinguishable from mechanical damage or failure to inflate after eclosion); overall, IP3K2wy-74i has the most severe phenotype, followed by IP3K2wy-2 and IP3K2wy-1 :

      (1) IP3K2wy-1/IP3K2wy-1 84%, IP3K2wy-1/IP3K2wy-2 33%, IP3K2wy-1/IP3K2wy-74i 13%, IP3K2wy-1/Df(1)Exel6245 0%;

      (2)IP3K2wy-1/IP3K2wy-1 13%, IP3K2wy-1/IP3K2wy-2 53%, IP3K2wy-1/IP3K2wy-74i 84%, IP3K2wy-1/Df(1)Exel6245 96%;

      (3)IP3K2wy-1/IP3K2wy-1 3%, IP3K2wy-1/IP3K2wy-2 13%, IP3K2wy-1/IP3K2wy-74i 3%, IP3K2wy-1/Df(1)Exel6245 4%.

      (Dean et al., 2015)

      Wings transversely waved, usually turned up at tip. Abdomen long and narrow. Marginal vein kinked even when other characters overlap wild type. RK2.

      (Lindsley and Zimm, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      IP3K2wy-1 has visible phenotype, suppressible by Itprug3/Itp-r83A[+]

      (Dean et al., 2015)

      IP3K2wy-1 has visible phenotype, suppressible by Itpr90B.0/Itp-r83A[+]

      (Dean et al., 2015)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      IP3K2wy-1 has wing phenotype, suppressible by Itprug3/Itp-r83A[+]

      (Dean et al., 2015)

      IP3K2wy-1 has wing phenotype, suppressible by Itpr90B.0/Itp-r83A[+]

      (Dean et al., 2015)
      NOT suppressed by
      Statement
      Reference

      IP3K2wy-1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Itp-r83Aug3/+ fully suppresses or Itp-r83A90B.0/+ almost fully suppresses the wing phenotypes seen in sibling IP3K2wy-1/IP3K2wy-1 control flies.

      (Dean et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      IP3K2wy-1 is rescued by IP3K2UAS.cDa

      (Dean et al., 2015)
      Comments

      IP3K2Scer\UAS.cDa (without a GAL4) fully rescues wing phenotypes in IP3K2wy-1/IP3K2wy-1 flies.

      (Dean et al., 2015)
      Images (1)
      Stocks (6)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      IP3K2wy-1
      wy1
      (Dean et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)