FlyBase Allele Report: Dmel\zen[7]

General Information

Symbol

Dmel\zen⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0018861

Feature type

allele

Associated gene

Dmel\zen

Associated Insertion(s)

Carried in Construct

Also Known As

zen^w36, EfW36

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Arora and Nusslein-Volhard, 1992, Ferguson and Anderson, 1992)

loss of function allele

(Ryu et al., 1997, Ray et al., 1991)

Mutagen

ethyl methanesulfonate

(Rushlow et al., 1987, Lewis et al., 1980)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Rushlow et al., 1987)

Description

Point mutation.

(Rushlow et al., 1987)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Lewis et al., 1980)

Phenotype Manifest In

adult optic lobe

(Wakimoto et al., 1984)

cuticle

(Wakimoto et al., 1984)

ectoderm | dorsal

(Rushlow and Levine, 1990)

mitotic domain 1 | extended germ band stage

(Wakimoto et al., 1984)

presumptive embryonic/larval central nervous system

(Wakimoto et al., 1984)

ventral denticle belt

(Wakimoto et al., 1984)

Detailed Description

Statement

Reference

Nondefective in gonad assembly.

(Warrior, 1994)

Weak ventralised phenotype. No amnioserosa and defects at the anterior segments.

(Arora and Nusslein-Volhard, 1992)

Embryos are ventralised.

(Ferguson and Anderson, 1992)

No salivary gland defects.

(Panzer et al., 1992)

Does not interact with RpII140^wimp maternal effect.

(Parkhurst and Ish-Horowicz, 1991)

Ventralized embryos: rings or patches of ventral denticles along dorsoventral axis. Disruption of germ band extension that leads to the invagination of posterior segments into the interior of the embryo.

(Ray et al., 1991)

Transformation in the cell fate of the dorsal most ectoderm toward a more ventral pathway of development during gastrulation. There is the correct number of body segments and the cuticular pattern elements associated with each element appear to be normal.

(Rushlow and Levine, 1990)

Embryos are dorsal defective.

(Carroll et al., 1987)

zen⁷/Df(3R)Scr embryos appear normal up to gastrulation. The germ band does not elongate, and one or two deep clefts appear between the cephalic furrow and posterior midgut rudiment. The embryo may appear twisted about the antero-posterior axis. Segmentation proceeds despite the distortion and the correct number of segments is formed. The head remains external and the CNS is disrupted. Normally non-adjacent segments are joined by stretches of cuticle in the late embryo, and there are disruptions in the larval setal belts. The optic lobe is absent.

(Wakimoto et al., 1984)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The embryonic midgut phenotype of maternal and zygotic lack^15C/lack^15C embryos is fully suppressed by heterozygosity for zen⁷.

(Podos et al., 2001)

Mutant phenotype is suppressed by increasing the dpp⁺ gene dosage.

(Ferguson and Anderson, 1992)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

zen⁷ is rescued by zen^+t4.5

(Rushlow et al., 1987)

Comments

Hemizygous mutant phenotype can be rescued by P element mediated transformation of a wild type zen gene. Homozygotes could not be rescued suggesting there may be an additional lethal mutation on the chromosome.

(Rushlow et al., 1987)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

2260

zen⁷ red¹ e¹/TM3, Sb¹ Ser¹

Kyoto

106759

zen⁷ red¹ e¹/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

Wakimoto.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

EfW36

(Denell, 1994, Lewis et al., 1980)

zen⁷

(Deignan et al., 2016, Dominguez et al., 2016, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Scuderi et al., 2006)

zen^W36

(Riede, 2004, Wimmer et al., 1995, Parkhurst and Ish-Horowicz, 1991)

zen^w36

(Liang et al., 2012, Lin et al., 2006, Xu et al., 2005, Podos et al., 2001, Rusch and Levine, 1997, Ryu et al., 1997, Tatei et al., 1995, Warrior, 1994, Winick et al., 1993, Arora and Nusslein-Volhard, 1992, Ferguson and Anderson, 1992, Panzer et al., 1992, Ray et al., 1991, Yamaguchi et al., 1991, Rushlow and Levine, 1990, Schulz and Miksch, 1989, Carroll et al., 1987, Rushlow et al., 1987, Wakimoto et al., 1984)

Name Synonyms

Secondary FlyBase IDs

References (33)

Report Sections

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