FlyBase Allele Report: Dmel\ttk[osn]

General Information

Symbol

Dmel\ttk^osn

Species

D. melanogaster

Name

oversensitive

FlyBase ID

FBal0024415

Feature type

allele

Associated gene

Dmel\ttk

Associated Insertion(s)

P{lacW}ttk^osn

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Giesen et al., 1997)

Mutagen

P-element activity

(Giesen et al., 1997)

Progenitor genotype

Associated Insertion(s)

P{lacW}ttk^osn

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Guo et al., 1995)

some die during embryonic stage | recessive

(Guo et al., 1995)

Phenotype Manifest In

Detailed Description

Statement

Reference

IIa precursor is transformed into a IIb precursor.

(Okabe et al., 2001)

Homozygotes have more sensory neurons than normal.

(Pi et al., 2001)

Overproduction of sensory neurons. Defects in the embryonic PNS, number of es and cho neurons is approximately doubled due to transformation of the outer support cell and cap cell respectively. Mosaic analysis demonstrates loss of ttk function in the adult leads to the appearance of supernumerary neurons at the expense of hair and socket cells.

(Guo et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ttk[+]/ttk^osn is an enhancer of visible phenotype of phyl²/phyl⁴

(Pi et al., 2001)

Suppressor of

Statement

Reference

ttk[+]/ttk^osn is a suppressor of visible | recessive phenotype of msi¹

(Okabe et al., 2001)

ttk[+]/ttk^osn is a suppressor of visible phenotype of sina³/sina²

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of visible phenotype of phyl²/phyl⁴

(Pi et al., 2001)

Other

Statement

Reference

Scer\GAL4^nanos.PG, run^UAS.cLa, ttk[+]/ttk^osn has lethal phenotype

(Vander Zwan et al., 2003)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

ttk^osn has sensory neuron | increased number phenotype, non-enhanceable by phyl¹/phyl²

(Pi et al., 2001)

NOT suppressed by

Statement

Reference

ttk^osn has external sensory organ precursor cell IIb | increased number phenotype, non-suppressible by msi¹/msi¹

(Okabe et al., 2001)

ttk^osn has external sensory organ precursor cell IIa phenotype, non-suppressible by msi¹/msi¹

(Okabe et al., 2001)

ttk^osn has sensory neuron | increased number phenotype, non-suppressible by phyl¹/phyl²

(Pi et al., 2001)

Enhancer of

Statement

Reference

ttk[+]/ttk^osn is an enhancer of adult abdominal segment 3 & chaeta phenotype of phyl²/phyl⁴

(Pi et al., 2001)

ttk[+]/ttk^osn is an enhancer of adult abdominal segment 3 & tormogen cell | supernumerary phenotype of phyl²/phyl⁴

(Pi et al., 2001)

ttk[+]/ttk^osn is an enhancer of adult abdominal segment 3 & trichogen cell | supernumerary phenotype of phyl²/phyl⁴

(Pi et al., 2001)

ttk[+]/ttk^osn is an enhancer of adult abdominal segment 4 & chaeta phenotype of phyl²/phyl⁴

(Pi et al., 2001)

ttk[+]/ttk^osn is an enhancer of adult abdominal segment 4 & tormogen cell | supernumerary phenotype of phyl²/phyl⁴

(Pi et al., 2001)

ttk[+]/ttk^osn is an enhancer of adult abdominal segment 4 & trichogen cell | supernumerary phenotype of phyl²/phyl⁴

(Pi et al., 2001)

Suppressor of

Statement

Reference

ttk[+]/ttk^osn is a suppressor of trichogen cell | increased number phenotype of msi¹

(Okabe et al., 2001)

ttk[+]/ttk^osn is a suppressor of mesothoracic tergum & trichogen cell | supernumerary phenotype of phyl²/phyl⁴

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of adult abdominal segment 3 & chaeta phenotype of sina³/sina²

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of adult abdominal segment 3 & microchaeta phenotype of sina³/sina²

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of adult abdominal segment 3 & tormogen cell | supernumerary phenotype of sina³/sina²

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of adult abdominal segment 3 & trichogen cell | supernumerary phenotype of sina³/sina²

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of adult abdominal segment 4 & chaeta phenotype of sina³/sina²

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of adult abdominal segment 4 & microchaeta phenotype of sina³/sina²

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of adult abdominal segment 4 & tormogen cell | supernumerary phenotype of sina³/sina²

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of adult abdominal segment 4 & trichogen cell | supernumerary phenotype of sina³/sina²

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of mesothoracic tergum & chaeta phenotype of sina³/sina²

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of mesothoracic tergum & tormogen cell | supernumerary phenotype of sina³/sina²

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of mesothoracic tergum & trichogen cell | supernumerary phenotype of sina³/sina²

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of eo neuron | embryonic stage phenotype of phyl¹/phyl²

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of adult abdominal segment 3 & microchaeta phenotype of phyl²/phyl⁴

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of adult abdominal segment 4 & microchaeta phenotype of phyl²/phyl⁴

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of mesothoracic tergum & chaeta phenotype of phyl²/phyl⁴

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of mesothoracic tergum & microchaeta phenotype of phyl²/phyl⁴

(Pi et al., 2001)

ttk[+]/ttk^osn is a suppressor of mesothoracic tergum & tormogen cell | supernumerary phenotype of phyl²/phyl⁴

(Pi et al., 2001)

ttk^osn is a suppressor of ommatidium phenotype of msi¹, sina³/sina²

(Hirota et al., 1999)

ttk^osn is a suppressor of rhabdomere phenotype of msi¹, sina³/sina²

(Hirota et al., 1999)

ttk^osn is a suppressor of cone cell phenotype of msi¹, sina³/sina²

(Hirota et al., 1999)

ttk^osn is a suppressor of phenotype of msi¹

(Hirota et al., 1999)

ttk^osn is a suppressor of phenotype of sina²

(Hirota et al., 1999)

ttk^osn is a suppressor of phenotype of sina³

(Hirota et al., 1999)

Other

Statement

Reference

msi¹, sina³/sina², ttk^osn has ommatidium phenotype

(Hirota et al., 1999)

msi¹, sina³/sina², ttk^osn has cone cell phenotype

(Hirota et al., 1999)

msi¹, sina³/sina², ttk^osn has rhabdomere phenotype

(Hirota et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The partial lethality due to run^Scer\UAS.cLa; Scer\GAL4^nos.PG (3% viable) is not suppressed by maternal heterozygosity for ttk^osn.

(Wheeler et al., 2002)

30% of the ommatidia of sina² msi¹ ttk^osn/sina³ msi¹ show the normal number and arrangement of photoreceptor cells. The cone cell defects of sina² msi¹/sina³ msi¹ are also suppressed by ttk^osn.

(Hirota et al., 1999)

numb¹;ttk^osn double mutant overproduces neurons, indistinguishable from ttk^osn mutant.

(Guo et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ttk^osn

(Liaw, 2022, Vander Zwan et al., 2003)

Name Synonyms

oversensitive

(Guo et al., 1995)

Secondary FlyBase IDs

References (10)

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