FB2024_03 , released June 25, 2024
Allele: Dmel\UbxCbx-M1
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General Information
Symbol
Dmel\UbxCbx-M1
Species
D. melanogaster
Name
FlyBase ID
FBal0028581
Feature type
allele
Associated gene
Dmel\Ubx
Associated Insertion(s)
Carried in Construct
Also Known As
CbxM1
Key Links
Allele class

neomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

neomorphic allele - genetic evidence

(Botas et al., 1988)
Mutagen
spontaneous
(Gonzalez-Gaitan et al., 1990)
X ray
(Botas et al., 1988)
Progenitor genotype
UbxCbx-1
(Gonzalez-Gaitan et al., 1990)
Caused by aberration
In(3R)CbxM1
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The mesothorax phenotype is reduced in combination with RpII215Ubl or RpS174. The dominant wing phenotype is 100% penetrant, occurring in the posterior and anterior compartment. UbxCbx-M1/Ubx195 transheterozygotes show transformation of T3p towards T2p, and A1a towards T3a.

      (Gonzalez-Gaitan et al., 1990)

      Phenotype is fully penetrant in heterozygotes, and shows constant specificity, affecting the wing margin dorsally and ventrally in both anterior and posterior compartments. Double heterozygotes between UbxCbx-M1 and Ubx alleles show strong bithoraxoid and postbithorax phenotypes.

      (Botas et al., 1988)

      Mesothoracic phenotype does not vary in the presence of extra copies of the bithorax complex, or with homologous chromosomes with breaks proximal to the bithorax complex.

      (Micol and Garcia-Bellido, 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      UbxCbx-M1 has visible | dominant | homeotic phenotype, non-enhanceable by za693

      (Micol and Garcia-Bellido, 1988)

      UbxCbx-M1 has visible | dominant | homeotic phenotype, non-enhanceable by za692

      (Micol and Garcia-Bellido, 1988)
      NOT suppressed by
      Statement
      Reference

      UbxCbx-M1 has visible | dominant | homeotic phenotype, non-suppressible by za692

      (Micol and Garcia-Bellido, 1988)

      UbxCbx-M1 has visible | dominant | homeotic phenotype, non-suppressible by za693

      (Micol and Garcia-Bellido, 1988)
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      UbxCbx-M1 has adult mesothoracic segment phenotype, non-enhanceable by za693

      (Micol and Garcia-Bellido, 1988)

      UbxCbx-M1 has adult mesothoracic segment phenotype, non-enhanceable by za692

      (Micol and Garcia-Bellido, 1988)
      NOT suppressed by
      Statement
      Reference

      UbxCbx-M1 has adult mesothoracic segment phenotype, non-suppressible by za692

      (Micol and Garcia-Bellido, 1988)

      UbxCbx-M1 has adult mesothoracic segment phenotype, non-suppressible by za693

      (Micol and Garcia-Bellido, 1988)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The Cbx mesothorax phenotype is reduced in a number of Cbx mutations in combination with RpII215Ubl. This reduction of the Cbx phenotype follows the order: UbxCbx-Hm > UbxCbx-2RM = UbxCbx-2 = UbxCbx-M1 > UbxCbx-1RM = UbxCbx-1 = UbxCbx-3 = UbxCbx-Twt. The Cbx mesothorax phenotype is reduced in a number of Cbx mutations in combination with RpS174. This reduction of the Cbx phenotype follows the order: UbxCbx-2RM > UbxCbx-2 = UbxCbx-M1 > UbxCbx-1 = UbxCbx-1RM.

      (Gonzalez-Gaitan et al., 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CbxM1
      (Weatherbee et al., 1998, Milan et al., 1997, Gonzalez-Gaitan et al., 1990, Botas et al., 1988, Micol and Garcia-Bellido, 1988)
      UbxCbx-M1
      Name Synonyms
      Secondary FlyBase IDs
        References (5)