FlyBase Allele Report: Dmel\Fas3[E25]

General Information

Symbol

Dmel\Fas3^E25

Species

D. melanogaster

Name

FlyBase ID

FBal0029780

Feature type

allele

Associated gene

Dmel\Fas3

Associated Insertion(s)

Carried in Construct

Also Known As

fasIII^E25

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Chiba et al., 1995, Reuter et al., 1993, Whitlock, 1993)

loss of function allele

(Kose et al., 1997)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | recessive

(Phillis et al., 1993)

abnormal neuroanatomy | embryonic stage, with Fas3^Mhc.PC

(Kose et al., 1997)

abnormal neuroanatomy | embryonic stage | recessive

(Kose et al., 1997)

abnormal neuroanatomy | larval stage, with Fas3^Mhc.PC

(Kose et al., 1997)

viable

(Chiba et al., 1995)

Phenotype Manifest In

dorsal appendage | maternal effect

(Ward and Berg, 2005)

embryonic hindgut (with Fas3^A142)

(Wells et al., 2013)

larval VL3/4 motor neuron

(Kose et al., 1997)

muscle cell of abdominal 2 ventral longitudinal muscle 3

(Kose et al., 1997)

muscle cell of abdominal 2 ventral longitudinal muscle 4

(Kose et al., 1997)

muscle cell of abdominal 3 ventral longitudinal muscle 3

(Kose et al., 1997)

muscle cell of abdominal 3 ventral longitudinal muscle 4

(Kose et al., 1997)

muscle cell of abdominal 4 ventral longitudinal muscle 3

(Kose et al., 1997)

muscle cell of abdominal 4 ventral longitudinal muscle 4

(Kose et al., 1997)

muscle cell of abdominal 5 ventral longitudinal muscle 3

(Kose et al., 1997)

muscle cell of abdominal 5 ventral longitudinal muscle 4

(Kose et al., 1997)

muscle cell of abdominal 6 ventral longitudinal muscle 3

(Kose et al., 1997)

muscle cell of abdominal 6 ventral longitudinal muscle 4

(Kose et al., 1997)

muscle cell of abdominal 7 ventral longitudinal muscle 3

(Kose et al., 1997)

muscle cell of abdominal 7 ventral longitudinal muscle 4

(Kose et al., 1997)

Detailed Description

Statement

Reference

Stage 15 embryonic hindguts of Fas3^A142/Fas3^E25 transheterozygotes have a lower angle of curvature, as compared to controls.

(Wells et al., 2013)

Homozygous Fas3^E25 null females lay eggs with normal length dorsal appendages but these appendages have stalks that are wider than normal and have a larger lumen.

(Ward and Berg, 2005)

The muscle 6/7 cleft is innervated normally in 91% of cases in homozygous 18 hour embryos. The RP3 growth cone misinnervates muscle 13 in 7% of cases. Innervation at the muscle 6/7 cleft is missing in 53% of cases in Fas3^E25 embryos carrying Fas3^Mhc.PC. In 43% of cases RP3 growth cones extend normally and innervate the 6/7 cleft. In another 43% of cases, after reaching the target region, the RP3 growth cones stall beneath the 6/7 cleft, and in 14% of cases the RP3 growth cones mistarget nearby muscles. The 6/7 cleft lacks normal innervation in 26% of cases in third stage Fas3^E25 larvae carrying Fas3^Mhc.PC, and the membranes of muscles 6 and 7 appear tightly adhered to each other, in contrast to wild-type.

(Kose et al., 1997)

Embryonic nervous system is normal and the axon pathway and target selections of both RP3 and RP1 motor neurons are normal.

(Chiba et al., 1995)

Slightly reduced grooming behavior.

(Phillis et al., 1993)

Homozygotes are viable and have no gross morphological abnormalities (Elkins, Ferres-Marco and Goodman). Increased branching of wing sensory axons in discs during metamorphosis: medial axons cross to the lateral tract.

(Whitlock, 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

4748

w^*; beat-Ia³ Fas3^E25/CyO, P{act-lacZ.B}CB1

Notes on Origin

Discoverer

Elkins.

(Reuter et al., 1993)

Comments

Null mutation resulting from the imprecise excision of a nearby P element.

(Whitlock, 1993)

Mutant embryos show no defect in midgut development.

(Reuter et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

FAS3^E25

(Kose et al., 1997)

Fas3^E25

(Zhang et al., 2018, Fabre et al., 2010, Geng and MacDonald, 2007, Roshina and Pasyukova, 2007, Girard et al., 2006)

Fas3^null

(Ward and Berg, 2005)

FasIII^E25

(Wells et al., 2013, Speicher et al., 1998)

fas3^E25

(Mora et al., 2013)

fasIII^E25

(Izumi et al., 2012, Behr et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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