FB2024_03 , released June 25, 2024
Allele: Dmel\Fas3A142
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General Information
Symbol
Dmel\Fas3A142
Species
D. melanogaster
Name
FlyBase ID
FBal0217008
Feature type
allele
Associated gene
Dmel\Fas3
Associated Insertion(s)
PBac{5HPw+}Fas3A142
Carried in Construct
Also Known As
fasIIIA142
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{5HPw+}Fas3A142
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Fas3A142 embryos do not have intersegmental nerve branch ISNb motor axon innervation defects.

        (Lu et al., 2014)

        The stage 15 embryonic hindguts of Fas3A142 homozygotes, or Fas3A142/Fas3k07109b or Fas3A142/Fas3E25 transheterozygotes have a lower angle of curvature, as compared to controls.

        Fas3A142 homozygous cell clones within a Fas3A142 heterozygote background in third instar larval wing discs have rounded clone boundaries, in contrast to control clones that have jagged boundaries.

        The epithelium of the dorsal wing hinge primordium in Fas3A142 homozygote third instar larval wing discs has an apparently normal fold morphology, as compared to controls.

        (Wells et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        Fas3A142/Fas3A142 is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of Nrgl4

        (Lu et al., 2014)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Fas3A142/Fas3A142 significantly enhances intersegmental nerve branch ISNb motor axon innervation defects (at m6/7) seen in Nrgl4/Nrgl4 embryos.

        (Lu et al., 2014)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (2)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Fas3A142
        FasIIIA142
        (Wells et al., 2013)
        fasIIIA142
        (Lu et al., 2014)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)