FlyBase Allele Report: Dmel\Sod1[X-39]

General Information

Symbol

Dmel\Sod1^X-39

Species

D. melanogaster

Name

FlyBase ID

FBal0030258

Feature type

allele

Associated gene

Dmel\Sod1

Associated Insertion(s)

Carried in Construct

Also Known As

Sod^x39, Sod1^x39

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

hypomorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Phillips et al., 1995)

hypomorphic allele - genetic evidence

(Staveley et al., 1991)

Mutagen

gamma ray

(Phillips et al., 1995)

Progenitor genotype

Cytology

Description

395bp deletion encompassing the transcription start site, all of the first exon and part of the single intron.

(Phillips et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:11,113,574..11,113,968 [-]

(Phillips et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of amyotrophic lateral sclerosis

CEA

(Parkes et al., 1998)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of amyotrophic lateral sclerosis

is ameliorated by Hsap\SOD1^UAS.cPa

(Parkes et al., 1998)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval hypodermal muscle cell | larval stage (with Sod1ⁿ¹)

(Ueda et al., 2021)

embryonic/larval neuromuscular junction | larval stage (with Sod1ⁿ¹)

(Ueda et al., 2021)

Detailed Description

Statement

Reference

Mutants show unusually high pupal mortality and adults have a severely truncated lifespan.

(Missirlis et al., 2003)

Sod^X-39/Sod^X-16 animals have a lifespan that is decreased by at least 77%.

(Mockett et al., 2003)

Sod1^X-39 homozygotes display reduced eclosion rate (difficulty completing metamorphosis) and severely decreased adult lifespan.

(Elia et al., 1999)

Homozygotes have a shorter lifespan than wild-type flies.

(Parkes et al., 1998)

Semilethal.

(Staveley et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Sod1^X-39 has short lived phenotype, suppressible by Hsap\SOD1^UAS.cPa/Scer\GAL4^Mhc.PW

(Missirlis et al., 2003)

Sod1^X-16/Sod1^X-39 has short lived phenotype, suppressible by Hsap\SOD1^G93C.Sod

(Mockett et al., 2003)

Sod1^X-16/Sod1^X-39 has short lived phenotype, suppressible | partially by Hsap\SOD1^A4V.Sod

(Mockett et al., 2003)

Sod1^X-16/Sod1^X-39 has short lived phenotype, suppressible | partially by Hsap\SOD1^G37R.Sod

(Mockett et al., 2003)

Sod1^X-16/Sod1^X-39 has short lived phenotype, suppressible | partially by Hsap\SOD1^G41D.Sod

(Mockett et al., 2003)

Sod1^X-16/Sod1^X-39 has short lived phenotype, suppressible by Hsap\SOD1^Sod.PM

(Mockett et al., 2003)

Sod1^X-39 has some die during P-stage phenotype, suppressible by Hsap\SOD1^G41S.UAS/Scer\GAL4^Toll-6-D42

(Elia et al., 1999)

Sod1^X-39 has short lived phenotype, suppressible by Hsap\SOD1^G41S.UAS/Scer\GAL4^Toll-6-D42

(Elia et al., 1999)

NOT suppressed by

Statement

Reference

Sod1^X-39 has short lived phenotype, non-suppressible by Sod2^UAS.cMa/Scer\GAL4^Toll-6-D42

(Missirlis et al., 2003)

Sod1^X-39 has short lived phenotype, non-suppressible by Sod2^UAS.cMa/Scer\GAL4^Mhc.PW

(Missirlis et al., 2003)

Sod1^X-39 has short lived phenotype, non-suppressible by Sod2^UAS.cMa/Scer\GAL4^da.G32

(Missirlis et al., 2003)

Sod1^X-16/Sod1^X-39 has short lived phenotype, non-suppressible by Hsap\SOD1^I113T.Sod

(Mockett et al., 2003)

Other

Statement

Reference

Hsap\SOD1^UAS.cPa, Scer\GAL4^Toll-6-D42, Sod1^X-39 has chemical resistant phenotype

(Parkes et al., 1998)

Hsap\SOD1^UAS.cPa, Scer\GAL4^Toll-6-D42, Sod1^X-39 has radiation resistant phenotype

(Parkes et al., 1998)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The addition of Hsap\SOD1^Sod.PM can suppress the reduced life-span phenotype of Sod^X-16/Sod^X-39 flies to effectively wild-type. The addition of Hsap\SOD1^A4V.Sod partially suppresses the reduced life-span phenotype of Sod^X-16/Sod^X-39 having an average 17-19% recovery of life span. These flies however, do not show a progressive age-related decrease in walking speed, instead these flies maintain the same motor ability as controls until 12 days of age, after which they show a rapid decline at approximately the age at which increased mortality rates are first observed. Female fertility is also initially unimpaired but subsequently undergoes a sharp decline. Flies are also normal in their response to oxidative challenge. The addition of Hsap\SOD1^G41D.Sod (specifically insertion P{dSod-hSod.G41D}1) partially suppresses the reduced life-span phenotype of Sod^X-16/Sod^X-39 having an average 26% recovery of life span, though some lines (P{dSod-hSod.G41D}2) do exhibit a reduced life span. These flies however, do not show a progressive age-related decrease in walking speed, instead these flies maintain the same motor ability as controls until 12 days of age, after which they show a rapid decline at approximately the age at which increased mortality rates are first observed. Female fertility is also initially unimpaired but subsequently undergoes a sharp decline. Flies are also normal in their response to oxidative challenge. The addition of Hsap\SOD1^G37R.Sod (specifically insertion P{dSod-hSod.G37R}1) can suppress the reduced life-span phenotype of Sod^X-16/Sod^X-39 flies to effectively wild-type, though some lines do exhibit a reduced life span. The addition of Hsap\SOD1^G93C.Sod (specifically insertion P{dSod-hSod.G93C}2) can suppress the reduced life-span phenotype of Sod^X-16/Sod^X-39 flies to effectively wild-type, though other lines do exhibit a variability in their ability to suppress the phenotype. The addition of Hsap\SOD1^I113T.Sod (specifically insertion P{dSod-hSod.I113T}1) cannot suppress the reduced life-span of Sod^X-16/Sod^X-39 flies.

(Mockett et al., 2003)

Both the reduced eclosion rate and the decreased adult lifespan characteristic for Sod1^X-39 homozygotes are significantly improved by expression of Hsap\SOD1^{G41S.Scer\UAS} under the control of Scer\GAL4^Toll-6-D42 in the mutant background. The partial lethality of Sod1^X-39 flies is also almost fully rescued by expression of Hsap\SOD1^Scer\UAS.cPa.

(Elia et al., 1999)

The shorter lifespan of Sod^X-39 flies is rescued (to greater than 60% of wild-type) in a dose-dependent manner by Hsap\SOD1^Scer\UAS.cPa expressed under the control of Scer\GAL4^D42. These flies also show enhanced resistance to paraquat and ionising radiation compared to Sod^X-39 flies which do not express Hsap\SOD1^Scer\UAS.cPa under the control of Scer\GAL4^D42.

(Parkes et al., 1998)

Complementation and Rescue Data

Rescued by

Sod1^X-16/Sod1^X-39 is rescued by Sod1^+t2.4

(Mockett et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

24490

Sod1^X-39 e¹/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

SOD^x39

(Elia et al., 1999)

Sod1^X-39

Sod1^X39

(Ueda et al., 2021)

Sod1^x39

(Blackney et al., 2014, Missirlis et al., 2003)

Sod^X-39

Sod^x39

(Blackney et al., 2014, Mockett et al., 2003, Parkes et al., 1998, Phillips et al., 1995)

dsod^X-39

(Şahin et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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