FlyBase Allele Report: Dmel\eya[E1]

General Information

Symbol

Dmel\eya^E1

Species

D. melanogaster

Name

FlyBase ID

FBal0030766

Feature type

allele

Associated gene

Dmel\eya

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Bui et al., 2000, Bonini et al., 1998, Bonini et al., 1993)

Progenitor genotype

Cytology

Description

Amino acid replacement: W646term.

(Tian et al., 2019, Bui et al., 2000)

Nucleotide substitution: G2332A.

(Bui et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:6,528,432..6,528,432 [-]

Nucleotide change:

G6528432A

Reported nucleotide change:

G2332A

Amino acid change:

W652term | eya-PA; W646term | eya-PB; W562term | eya-PC

Reported amino acid change:

W646term

(Bui et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage (with eya¹)

(Tian et al., 2019)

abnormal size | adult stage (with eya²)

(Tian et al., 2019)

lethal | recessive

(Bonini et al., 1998)

lethal - all die during embryonic stage (with eya^E(P)10)

(Bui et al., 2000)

partially lethal | recessive

(Leiserson et al., 1998)

some die during embryonic stage (with eya^E(P)10)

(Bui et al., 2000)

visible (with eya¹)

(Bui et al., 2000)

visible | adult stage (with eya¹)

(Tian et al., 2019)

visible | adult stage (with eya²)

(Tian et al., 2019)

visible | adult stage (with eya⁴)

(Tian et al., 2019)

visible | adult stage (with In(2LR)ETD2.2)

(Tian et al., 2019)

visible | recessive

(Bonini et al., 1998, Leiserson et al., 1998, Bonini et al., 1993)

Phenotype Manifest In

eye

(Bonini et al., 1998, Leiserson et al., 1998)

eye (with eya¹)

(Tian et al., 2019, Bui et al., 2000, Bui et al., 2000)

eye (with eya²)

(Tian et al., 2019)

eye (with eya⁴)

(Tian et al., 2019)

eye (with In(2LR)ETD2.2)

(Tian et al., 2019)

Detailed Description

Statement

Reference

eya^E1/eya⁴ adults and majority of eya^E1/In(2LR)ETD2.2 adults are eyeless.

eya¹/eya³ and eya¹/eya⁴ adults exhibit significantly higher number of ommatidia in the eye than eya¹/eya^E1 adults.

eya²/eya⁴ and eya²/eya³ adults exhibit significantly higher number of ommatidia in the eye than eya²/eya^E1 adults.

(Tian et al., 2019)

eya¹/eya^E1 flies are eyeless or have eyes reduced to less than 1/4 normal size. More than 50% of eya^E1/eya^E(P)10 animals die as embryos.

(Bui et al., 2000)

eya^E1/eya¹ flies and eya^E1/eya³ flies are eyeless.

(Bonini et al., 1998)

Less than 50% of eya^E1/Df(2L)eya¹⁰ embryos hatch. Less than 50% of eya^E1/eya^E3 animals survive to adulthood. Adults have eyes which are less than 1/2 normal size. eya^E1/eya⁴ flies are eyeless.

(Leiserson et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

eya¹

(Tian et al., 2019)

eya²

(Tian et al., 2019)

eya¹

(Bonini et al., 1993)

Fails to complement

eya⁴

(Tian et al., 2019)

Comments

Fails to complement eye phenotype of eya¹.

(Bonini et al., 1993)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

cli^eya-E1

eya^E1

(Tian et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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