FB2024_03 , released June 25, 2024
Allele: Dmel\drkR1
Open Close
General Information
Symbol
Dmel\drkR1
Species
D. melanogaster
Name
FlyBase ID
FBal0031080
Feature type
allele
Associated gene
Dmel\drk
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Diaz-Benjumea and Hafen, 1994)

loss of function allele

(Olivier et al., 1993)
Mutagen
ethyl methanesulfonate
(Olivier et al., 1993)
Progenitor genotype
Cytology
Description

Amino acid replacement: A67H.

(Moressis et al., 2009)

Amino acid replacement: R67H. R67H affects a highly conserved residue among SH2 domains.

(Olivier et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:13,497,709..13,497,709 [-]
Nucleotide change:

G13497709A

Amino acid change:

R67H | drk-PA; R67H | drk-PB; R67H | drk-PC; R67H | drk-PD; R67H | drk-PF

Reported amino acid change:

R67H

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Olivier et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The hatching rate for drkR1 heterozygotes is 96.4%

      (Li et al., 2009)

      Olfactory association learning is lower in drkR1 heterozygotes compared to controls.

      (Moressis et al., 2009)

      Removal of one copy of dos from sev::tor13D:Y2546F.hs.sev individuals causes a significant reduction in ommatidia with multiple R7 cells.

      (Raabe et al., 1996)

      Clonal analysis reveals phenotypes in the adult including loss of wing vein, ectopic wing vein, reduced cell size and extra bristles.

      (Diaz-Benjumea and Hafen, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      drkR1 is a suppressor of photoreceptor cell R7 phenotype of sev::tor13D.hs.sev

      (Raabe et al., 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Suppresses the extra R7 phenotype of sev::tor13D.hs.sev : sev::tor13D.hs.sev; drkR1/+ flies have 33% of ommatidia with multiple R7 cells as opposed to 99% for sev::tor13D.hs.sev flies.

      (Raabe et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      The lethality seen in drkR1/drkE(sev)2B transheterozygotes can be rescued by drk product supplied under a heat shock promoter.

      (Olivier et al., 1993)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      drkR1
      (Zhang et al., 2013, Li et al., 2009, Moressis et al., 2009)
      drkSu(sev)R1
      (Olivier et al., 1993)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)