FlyBase Allele Report: Dmel\neur[A101]

General Information

Symbol

Dmel\neur^A101

Species

D. melanogaster

Name

FlyBase ID

FBal0032226

Feature type

allele

Associated gene

Dmel\neur

Associated Insertion(s)

P{lArB}neur^A101

Carried in Construct

Also Known As

neur-lacZ, neur^A101-lacZ, A101-lacZ, neu-LacZ, neu^A101, neuralized-lacZ, neu^A101-lacZ, A101, neur-lacZ^A101

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lai et al., 2005)

Mutagen

P-element activity

(Huang et al., 1995, Blair, 1993, Heitzler and Simpson, 1993, Ramain et al., 1993)

Progenitor genotype

Associated Insertion(s)

P{lArB}neur^A101

Cytology

Description

P element insertion maps to an approximately 3kb HindIII fragment that includes the 5' end of the neur transcription unit.

(Price et al., 1993)

P-element insertion in 5' flanking region.

(Boulianne et al., 1991)

Allele components

Component

Use(s)

Inserted element

P{lArB}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | somatic clone

(Lai and Rubin, 2001)

Phenotype Manifest In

chemosensory ventral triple row bristle | somatic clone | increased number

(Lai and Rubin, 2001)

eye | somatic clone

(Lai and Rubin, 2001, Yeh et al., 2000)

eye photoreceptor cell | somatic clone

(Yeh et al., 2000)

interommatidial bristle | ectopic | somatic clone

(Yeh et al., 2000)

interommatidial bristle | somatic clone

(Yeh et al., 2000)

interommatidial bristle | somatic clone | increased number

(Lai and Rubin, 2001)

macrochaeta & mesothoracic tergum | supernumerary | somatic clone

(Lai et al., 2005)

macrochaeta | cell autonomous | ectopic | somatic clone

(Yeh et al., 2000)

macrochaeta | somatic clone | increased number

(Lai and Rubin, 2001)

mechanosensory ventral triple row bristle | somatic clone

(Lai and Rubin, 2001)

microchaeta | cell autonomous | ectopic | somatic clone

(Yeh et al., 2000)

microchaeta | somatic clone | increased number

(Lai and Rubin, 2001)

ommatidium | somatic clone

(Lai and Rubin, 2001, Yeh et al., 2000)

rhabdomere | somatic clone

(Lai and Rubin, 2001)

sensory mother cell | ectopic | somatic clone

(Yeh et al., 2000)

wing margin bristle | ectopic | somatic clone

(Yeh et al., 2000)

wing vein | ectopic | somatic clone

(Yeh et al., 2000)

Detailed Description

Statement

Reference

neur^A101 mutant C4da neuronal clones do not exhibit defects in dendrite pruning or neuronal cell death 18-20 hours after puparium formation.

(Kuo et al., 2006)

neur^A101 clones in the adult notum display tufted bristles as a result of a mild defect in sensory precursor restriction , and subsequent development of supernumerary sensilla with normal cell complements.

(Lai et al., 2005)

Mutants show no obvious mushroom body defect.

(Watts et al., 2003)

Homozygous somatic clones in the notum display an autonomous increase in microchaetae density as well as tufts of microchaetes and macrochaetes. Homozygous somatic clones in the adult wing display an increase in chemosensory bristles and lack most stout mechanosensory organs.

(Lai and Rubin, 2001)

Homozygous somatic clones in the eye produces eyes that contain ommatidia of variable sizes (including many that are larger than normal), frequent tufting of interommatidial bristles, and glazed or scarred regions. Ommatidia contain variable numbers of rhabdomeres and frequent fusion of ommatidial clusters.

(Lai and Rubin, 2001)

Homozygous mutant clones display a bristle tufting phenotype affecting both macrochaetae and microchaetae. The severity of the phenotype ranged from duplicated bristles to tufts containing several bristles. Supernumerary macrochaetae and macrochaetae are always found in characteristically normal positions. Tufting can also be observed with adult head sensillae surrounding the eye and ocelli. In addition, bristle sensilla throughout the body, including the dorsal and ventral abdomen, also appear to form tufts. As is observed for macrochaetae. these tufts always occur in locations where normal bristles are formed. Homozygous mutant clones in the eye can also cause eye defects. producing irregularly shaped ommatidia, mispositioned or extra sensory bristles, severe scarring and defective photoreceptor development. Homozygous mutant clones also cause defects in wing development, including irregular wing margin sensory bristle formation and ectopic wing vein formation.

(Yeh et al., 2000)

emc^E12/emc¹¹ neur^A101 larvae have very low viability.

(Huang et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

neur^A101 is a suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

neur^A101 is a suppressor of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

neur^A101 is an enhancer of phenotype of Brd¹

(Leviten and Posakony, 1996)

neur^A101 is an enhancer of phenotype of Brd³

(Leviten and Posakony, 1996)

NOT Enhancer of

Statement

Reference

neur^A101 is a non-enhancer of scutellar bristle | ectopic phenotype of E(spl)m4-BFM^UAS.cAa, Scer\GAL4^ptc-559.1

(Apidianakis et al., 1999)

Suppressor of

Statement

Reference

neur^A101 is a suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

neur^A101 is a suppressor of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

NOT Suppressor of

Statement

Reference

neur^A101 is a non-suppressor of scutellar bristle | ectopic phenotype of E(spl)m4-BFM^UAS.cAa, Scer\GAL4^ptc-559.1

(Apidianakis et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The presence of neur^A101 does not affect the supernumerary phenotype seen in flies with m4^Scer\UAS.cAa driven by Scer\GAL4^ptc-559.1.

(Apidianakis et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

neur^A101 is rescued by neur^UAS.cLa/Scer\GAL4^sca-537.4

(Lai et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4369

P{lArB}neur^A101 ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

23865

w^*; P{PZ}Cul3⁰⁶⁴³⁰ P{neoFRT}40A/CyO, P{hs-hid}4; P{lArB}neur^A101/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

A101

(Yamaguchi et al., 1994)

neu^A101

(Sen et al., 2003, Lai and Rubin, 2001, Jhaveri et al., 2000, Yeh et al., 2000)

neur^A101

(Ulvklo et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (28)

Report Sections

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