FlyBase Allele Report: Dmel\pros[m4]

General Information

Symbol

Dmel\pros^m4

Species

D. melanogaster

Name

FlyBase ID

FBal0032484

Feature type

allele

Associated gene

Dmel\pros

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Doe et al., 1991)

Mutagen

ethyl methanesulfonate

(Hill et al., 1995, Doe et al., 1991)

X ray

(Hill et al., 1995)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Doe et al., 1991)

abnormal neuroanatomy | embryonic stage 16

(Kohsaka and Nose, 2009)

lethal - all die during embryonic stage

(Doe et al., 1991)

some die during embryonic stage

(Doe et al., 1991)

Phenotype Manifest In

Detailed Description

Statement

Reference

Extension of motoneuron axons is severely delayed in pros^m4 mutant embryos.

(Kohsaka and Nose, 2009)

Mutants show no repo-positive cells of the NB6-4T or NB7-4 lineage. NB6-4T produces the normal number of progeny but none adopt the glial fate, all remaining in the neuronal, lateral position. NB6-4A is not affected by pros mutants.

(Akiyama-Oda et al., 2000)

Haploinsufficiency for Abl, loss of one gene copy of pros exacerbates the Abl^- mutant phenotype. Homozygotes exhibit complete fusion of anterior and posterior commissure axon bundles and absence of longitudinal bundles. Mutant phenotype is not detectably altered in the absence of Abl.

(Gertler et al., 1993)

Severe CNS defects. The aCC and pCC neurons have abnormal axon morphology. Cells involved in the circumferential or mediolateral condensation of the CNS may be defective: nerve cord condensation along the mediolateral axis is retarded and there are often gaps along the midline.

(Doe et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

pros^m4 is an enhancer of lethal phenotype of Abl¹

(Gertler et al., 1989)

pros^m4 is an enhancer of lethal phenotype of Abl²

(Gertler et al., 1989)

Phenotype Manifest In

Other

Statement

Reference

mira^L44, pros^m4 has embryonic/larval glial cell phenotype

(Akiyama-Oda et al., 2000)

mira^L44, pros^m4 has thoracic neuroblast NB6-4 phenotype

(Akiyama-Oda et al., 2000)

mira^L44, pros^m4 has neuroblast NB7-4 phenotype

(Akiyama-Oda et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Enhance the Abl¹ and Abl² mutant phenotype from pupal lethal to embryonic or larval lethality by an haploinsufficiency dependent on Abl (HDA).

(Gertler et al., 1989)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

"X ray" was stated as tentative. "ethyl methanesulfonate" was stated as tentative. Haploinsufficiency dependent upon an Abl mutant background (HDA).

(Hill et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

(Gertler et al., 1989)

pros^M4

(Hill et al., 1995, Gertler et al., 1993)

pros^m4

(Kohsaka and Nose, 2009, Kohsaka et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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