FlyBase Allele Report: Dmel\sc[hb.PP]

General Information

Symbol

Dmel\sc^hb.PP

Species

D. melanogaster

Name

hunchback promoter construct of Parkhurst

FlyBase ID

FBal0032646

Feature type

allele

Associated gene

Dmel\sc

Associated Insertion(s)

Carried in Construct

P{hb-sc}

Key Links

Transgenic product class

wild_type

(Parkhurst et al., 1990)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Parkhurst et al., 1990)

Mutagen

in vitro construct

(Shoop and Parkhurst, 1995, Parkhurst et al., 1993, Parkhurst et al., 1990)

Progenitor genotype

Carried in construct

P{hb-sc}

Cytology

Description

The hb promoter drives expression of the sc coding region.

(Parkhurst et al., 1990)

Allele components

Component

Use(s)

Regulatory region(s)

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | female

(Dawson et al., 1995)

lethal | male

(Dawson et al., 1995, Shoop and Parkhurst, 1995, Parkhurst et al., 1993, Parkhurst et al., 1990)

Phenotype Manifest In

head | male

(Parkhurst et al., 1990)

Detailed Description

Statement

Reference

2 copies of sc^hb.PP cause male lethality.

(Dawson et al., 1995)

Male-specific lethality due to inappropriate activation of Sxl. Can rescue the female lethality of h^hb.PP.

(Shoop and Parkhurst, 1995)

Causes male specific lethality and activates ectopic Sxl expression in the anterior of male embryos (Parkhurst et al., Cell 63: 1179--1191.)

(Parkhurst et al., 1993)

Female viability is unaffected. Head morphology of males is defective.

(Parkhurst et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

sc^hb.PP has lethal | male phenotype, suppressible by hry^hb.PP

(Dawson et al., 1995, Parkhurst et al., 1993)

sc^hb.PP has lethal | female phenotype, suppressible by E(spl)m8-HLH::hry^b

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, suppressible by E(spl)m8-HLH::hry^bHLH

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, suppressible by E(spl)m8-HLH::hry^HLH

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, suppressible by E(spl)m8-HLH::hry^Or

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, suppressible by E(spl)m8-HLH::hry^OrW.2

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, suppressible by E(spl)m8-HLH::hry^W

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, suppressible by hry^ΔSPPSS.hb

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, suppressible by hry^ΔWRPW.hb

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, suppressible by hry^hb.PP

(Dawson et al., 1995)

sc^hb.PP has lethal | male phenotype, suppressible by Xlae\h^hb.PD

(Dawson et al., 1995)

sc^hb.PP has lethal | male phenotype, suppressible by Sxl^M1

(Parkhurst et al., 1990)

NOT suppressed by

Statement

Reference

sc^hb.PP has lethal | male phenotype, non-suppressible by E(spl)m8-HLH^hb.PD

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by da::hry^b

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by hry^MR.hb

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by hry^P37N.hb

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by hry^P37T.hb

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by hry^PNMR.hb

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by hry^RIP.hb

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by hry::sc^b

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by hry::sc^bHLH

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by da::hry^bHLH

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by da::hry^HLH

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by E(spl)m8-HLH^hb.PD

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by E(spl)m8-HLH::hry^OrW.1

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by hry^ΔOrange.hb

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by hry^M39L.hb

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by hry^M39R.hb

(Dawson et al., 1995)

sc^hb.PP has lethal | female phenotype, non-suppressible by hry^ML.hb

(Dawson et al., 1995)

Other

Statement

Reference

hry^hb.PP, sc^hb.PP has viable | male phenotype

(Parkhurst et al., 1993)

Sxl^M1, sc^hb.PP has viable | male phenotype

(Parkhurst et al., 1990)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Expression of h^hb.PP can rescue male lethality caused by sc^hb.PP. Deletion of the bHLH and orange domains of h render it unable to rescue male lethality, the WRPW domain is not required for rescue. Expression of E(spl)^hb.PD cannot rescue male lethality caused by sc^hb.PP.

(Dawson et al., 1995)

Ectopic h expression (h^hb.PP) rescues sc^hb.PP male lethality. Extra copies of da⁺ do not effect male lethality of sc^hb.PP.

(Parkhurst et al., 1993)

sc^hb.PP/Sxl^M1 male embryos are fully viable.

(Parkhurst et al., 1990)

Xenogenetic Interactions

Statement

Reference

Expression of Xlae\h^hb.PD can rescue male lethality caused by sc^hb.PP.

(Dawson et al., 1995)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Parkhurst.

(Parkhurst et al., 1993)

Comments

Restores posterior Sxl protein expression in sc^sisB-1 female embryos. sc^sisB-1; l(1)sc^hb.PP and sisA¹; sc^hb.PP embryos lack posterior Sxl expression.

(Parkhurst et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sc^hb.PP

Name Synonyms

hunchback promoter construct of Parkhurst

(Parkhurst et al., 1990)

Secondary FlyBase IDs

References (4)

Report Sections

Open Close