FB2024_03 , released June 25, 2024
Allele: Dmel\squPP32
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General Information
Symbol
Dmel\squPP32
Species
D. melanogaster
Name
FlyBase ID
FBal0032778
Feature type
allele
Associated gene
Dmel\squ
Associated Insertion(s)
Carried in Construct
Also Known As
squPP
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Schupbach and Wieschaus, 1991)
Progenitor genotype
Cytology
Description

Amino acid replacement: L111term.

(Pane et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:16,681,050..16,681,050 [+]
Nucleotide change:

T16681050A

Amino acid change:

L111term | squ-PA; L111term | squ-PB; L111term | squ-PC

Reported amino acid change:

L111term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Pane et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      squHE47/squPP32 females lay eggs with a range of dorsoventral patterning defects; 55.4% have a single dorsal appendage or the appendages are fused at the base, 44.2% have no dorsal appendage or are collapsed and only 0.4% are similar to wild type.

      (Pane et al., 2007)

      Most extreme eggs are spindle shaped without dorsal appendages. Other eggs have fused dorsal appendages or of normal morphology but remain unfertilized.

      (Schupbach and Wieschaus, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      squ[+]/squPP32 is an enhancer of abnormal meiotic cell cycle phenotype of RanGAPSd

      (Gell and Reenan, 2013)
      Suppressor of
      Statement
      Reference

      squ[+]/squPP32 is a suppressor of abnormal meiotic cell cycle phenotype of RanGAPSd

      (Gell and Reenan, 2013)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      squHE47/squPP32 has egg phenotype, suppressible by lokp6/lokp6

      (Pane et al., 2007)

      squHE47/squPP32 has dorsal appendage phenotype, suppressible by lokp6/lokp6

      (Pane et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The segregation distortion seen in males carrying either the SD-5star or SD-72 Dp(2;2)RanGAPSD chromosome variant (in a sensitive Rsp background) is suppressed (the k[[c]] value, or proportion of Dp(2;2)RanGAPSD-bearing progeny as the fraction of total progeny (corrected for viability), is significantly decreased) if the males are also carrying a single copy of squPP32.

      The segregation distortion seen in males carrying the SD-LosArenos Dp(2;2)RanGAPSD chromosome variant (in a sensitive Rsp background) is enhanced (the k[[c]] value, or proportion of Dp(2;2)RanGAPSD-bearing progeny as the fraction of total progeny (corrected for viability), is significantly increased) if the males are also carrying a single copy of squPP32.

      (Gell and Reenan, 2013)

      The dorsoventral patterning defects seen in eggs derived from squHE47/squPP32 females are nearly completely suppressed if the females are also homozygous for lokp6; 9.3% have a single dorsal appendage or the appendages are fused at the base and 90.6% of the eggs are similar to wild type.

      (Pane et al., 2007)

      Mutation does not suppress the bicaudal phenotype of oskbcd.3UTR.T:Zzzz\His6.

      (Wilson et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      squPP32
      (Patil et al., 2014, Kibanov et al., 2011, Nagao et al., 2010, Rouget et al., 2010, Pane et al., 2007)
      squPP
      (Gell and Reenan, 2013, Pane et al., 2007)
      squPP32
      (Haase et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)