FlyBase Allele Report: Dmel\sti[2]

General Information

Symbol

Dmel\sti²

Species

D. melanogaster

Name

FlyBase ID

FBal0032820

Feature type

allele

Associated gene

Dmel\sti

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl nitrosourea

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(D'Avino et al., 2004, Carpenter, 1994)

Mutagen

ethyl nitrosourea

(Carpenter, 1994)

Progenitor genotype

Cytology

Description

The mutation results in a product lacking the C1 and Citron Homology domains and the last portion of the coiled-coil region.

(D'Avino et al., 2004)

Amino acid replacement: K1125S.

(D'Avino et al., 2004)

Amino acid replacement: ?1126term.

(D'Avino et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

3L:12,510,651..12,510,679 [-]

Reported amino acid change:

?1126term

Inserted_sequence:

GTTGATCTCAAGCCTCA

Comment:

Mutation is a deletion of 29 nucleotides and an associated insertion of 17 nucleotides. This introduces a stop at codon 1126.

(D'Avino et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle

(Carpenter, 1994)

lethal - all die before end of prepupal stage (with Df(3L)F10)

(D'Avino et al., 2004)

lethal - all die before end of prepupal stage (with sti¹)

(D'Avino et al., 2004)

lethal - all die before end of prepupal stage (with sti³)

(D'Avino et al., 2004)

lethal - all die before end of prepupal stage (with sti⁴)

(D'Avino et al., 2004)

partially lethal - majority die | adult stage (with sti⁵)

(D'Avino et al., 2004)

partially lethal - majority die | pharate adult stage (with sti⁵)

(D'Avino et al., 2004)

some die during prepupal stage | recessive (with Df(3L)F10)

(D'Avino et al., 2004)

some die during prepupal stage | recessive (with sti¹)

(D'Avino et al., 2004)

some die during prepupal stage | recessive (with sti³)

(D'Avino et al., 2004)

some die during prepupal stage | recessive (with sti⁴)

(D'Avino et al., 2004)

Phenotype Manifest In

imaginal disc

(D'Avino et al., 2004)

imaginal disc (with Df(3L)F10)

(D'Avino et al., 2004)

imaginal disc (with sti³)

(D'Avino et al., 2004)

imaginal disc (with sti⁴)

(D'Avino et al., 2004)

Detailed Description

Statement

Reference

sti² homozygous, sti²/sti³, sti²/sti⁴, and sti²/Df(3L)F10 larvae have very small imaginal discs and are lethal at the prepupal stage.

(D'Avino et al., 2004)

In trans to a deficiency, mitotic chromosomes (both sisters and heterologues) stuck together and show metaphase delay; "successful" anaphase fragments the chromosomes.

(Carpenter, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Carpenter.

(Carpenter, 1994)

Comments

Based on lethal phase analysis the following sti alleles can be ranked from the most severe to the weakest as follows: sti³ > sti¹ = sti² = sti⁴ > sti⁵.

(D'Avino et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sti²

(D'Avino et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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