FB2024_03 , released June 25, 2024
Allele: Dmel\Chc3
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General Information
Symbol
Dmel\Chc3
Species
D. melanogaster
Name
FlyBase ID
FBal0033513
Feature type
allele
Associated gene
Dmel\Chc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Windler and Bilder, 2010)
Mutagen
ethyl methanesulfonate
(Katzen and Bishop, 1996, Bazinet et al., 1993, Katzen, 1990)
Progenitor genotype
Cytology
Description

A nonsense mutation within the third coding exon.

(Windler and Bilder, 2010)

Amino acid replacement: R366term.

(Windler and Bilder, 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:15,832,408..15,832,408 [-]
Nucleotide change:

C15832408T

Amino acid change:

R366term | Chc-PA; R366term | Chc-PB; R366term | Chc-PC; R366term | Chc-PD; R366term | Chc-PE; R366term | Chc-PF; R366term | Chc-PG

Reported amino acid change:

R366term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Windler and Bilder, 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mutant imaginal discs show neoplastic phenotypes.

      Egg chambers containing Chc3 mutant germline clones show morphological defects.

      (Windler and Bilder, 2010)

      No defects are seen in axon pruning during metamorphosis, or defects seen in the mushroom body.

      (Watts et al., 2003)

      Germline clonal analysis demonstrates an autonomous cell-lethal mutation in the female germline. Most embryos succeed in hatching, unhatched embryos show no regular cuticle defect.

      (Bazinet et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      ChcAA1/Chc3 is rescued by Chc+t13

      (Eun et al., 2007)

      Chc3/ChcBB2 is rescued by Chc+t13

      (Eun et al., 2007)

      Chc3 is rescued by Chc+t13

      (Bazinet et al., 1993)
      Not rescued by

      Chc3 is not rescued by ChcCHC2

      (Bazinet et al., 1993)

      Chc3 is not rescued by ChcCHC9

      (Bazinet et al., 1993)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Chc3
      (de Vreede et al., 2014, Windler and Bilder, 2010)
      EM41
      chc3
      (Eun et al., 2007)
      em41
      (Katzen and Bishop, 1996)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0039457
      References (7)