FB2024_03 , released June 25, 2024
Allele: Dmel\cniAA12
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General Information
Symbol
Dmel\cniAA12
Species
D. melanogaster
Name
FlyBase ID
FBal0034361
Feature type
allele
Associated gene
Dmel\cni
Associated Insertion(s)
Carried in Construct
Also Known As
cniAA
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Roth et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: W87term.

(Roth et al., 1995)

Nucleotide substitution: G353A.

(Roth et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:16,310,269..16,310,269 [-]
Nucleotide change:

G16310269A

Reported nucleotide change:

G353A|FBrf0082538

Amino acid change:

W87term | cni-PA; W87term | cni-PB; W87term | cni-PC

Reported amino acid change:

W87term

(Roth et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eggs from cni1/cniAA12 females are ventralised (reduction of dorsal appendages), while the anterior and posterior structures differentiate correctly.

      (Bokel et al., 2006)

      In 70% of cni1/cniAA12 mutants, the nucleus fails to move to the dorsal/anterior corner and is mislocalized at the posterior pole.

      (Herpers and Rabouille, 2004)

      cni1/cniAA12 females lay ventralised eggs with apparently normal anterior-posterior polarity. The oocyte nucleus is localised normally in the egg chambers of these females.

      (Peri and Roth, 2000)

      Homozygous embryos exhibit a germline-dependent ventralised phenotype. cni1/cniAA12 transheterozygotes have mutant egg chambers.

      (Gonzalez-Reyes et al., 1995)

      Hemizygous eggs display possess residual dorsal appendage material and rarely a posterior micropyle. Most cniAA12/cni1 heterozygous embryos have one reduced dorsal appendage, few have a posterior micropyle, and a third of the eggs contain no embryos. twi expression domain show a duplication of the mesodermal analgen.

      (Roth et al., 1995)

      Strong ventralisation of embryos.

      (Christerson and McKearin, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The synthetic lethality found in a synthetic cniAA12/cni1 and Df(2L)JS7 heterozygous background can be suppressed through expression of cnircniUTR.PB.

      (Bokel et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Ashburner.

      (Neuman-Silberberg and Schupbach, 1993)
      Comments
      Comments

      Intermediate cni allele.

      (Roth et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cniAA12
      (Bokel et al., 2006)
      cniAA
      (Snee and Macdonald, 2009, Lei and Warrior, 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (12)