FB2024_03 , released June 25, 2024
Allele: Dmel\pdm2hs.P
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General Information
Symbol
Dmel\pdm2hs.P
Species
D. melanogaster
Name
FlyBase ID
FBal0034399
Feature type
allele
Associated gene
Dmel\pdm2
Associated Insertion(s)
Carried in Construct
P{hsp70-pdm2}
Key Links
Transgenic product class
wild_type
(Yang et al., 1993)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Yang et al., 1993)
Mutagen
in vitro construct
(Bhat et al., 1995, Yang et al., 1993, Yang et al., 1993)
Progenitor genotype
Carried in construct
P{hsp70-pdm2}
Cytology
Description

pdm2 expression is driven by a minimal Hsp70 promoter.

(Yang et al., 1993)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
pdm2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In pdm2hs.P embryos heat shocked (90 minutes; 37oC) at 6.45 hours (raised at 22oC), the prescence of 1-2 ectopic RP2 neurons in many hemisegments at stage 14 of embryogenesis is indicated by marker expression and morphological analysis. At stage 12 an 63% of hemisegments in these embryos have an extra 3-5 cells clustered with the developing RP2 neuron and its sib.

      (Bhat and Apsel, 2004)

      The RP2 neurons are duplicated in 2 to 6 hemisegments in approximately 71% of embryos heat shocked at 7 hours of development.

      (Bhat et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      pdm2hs.P has larval RP2 motor neuron | ectopic phenotype, enhanceable by insc22/insc22

      (Bhat and Apsel, 2004)
      Suppressed by
      Statement
      Reference

      pdm2hs.P has larval RP2 motor neuron | ectopic phenotype, suppressible by numb796/numb796

      (Bhat and Apsel, 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heat-shocked, stage 14 pdm2hs.P; insc22/insc22 embryos have extra RP2 neurons, but not extra RP2 sibs. Heat-shocked, stage 14 pdm2hs.P; numb796/numb796 embryos have extra RP2 sibs, but not extra RP2 neurons.

      (Bhat and Apsel, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Partially rescues the RP2/sib lineage defect of Df(2L)prd1.7 flies when expressed using heat shock during the time of GMC-1 formation.

      (Bhat et al., 1995)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      pdm2hs.P
      Name Synonyms
      Secondary FlyBase IDs
        References (6)