FlyBase Allele Report: Dmel\en[Xho25]

General Information

Symbol

Dmel\en^Xho25

Species

D. melanogaster

Name

FlyBase ID

FBal0034517

Feature type

allele

Associated gene

Dmel\en

Associated Insertion(s)

P{en-lacZ(Xho)}en^Xho25

Carried in Construct

Also Known As

en-lacZ, ryxho25, engrailed-lacZ, PlacZ rhx25, en^Xho25-lacZ

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

P-element activity

(Vincent and O'Farrell, 1992, Simcox et al., 1989)

p pi25.7wc

(Hama et al., 1990)

Progenitor genotype

Ecol\lacZ^en.Xho

(Hama et al., 1990)

Associated Insertion(s)

P{en-lacZ(Xho)}en^Xho25

Cytology

Description

Maps to approximate coordinate -12 of the inv-en region.

(Gustavson et al., 1996)

Insertion of a transposon carrying 5.7kb of en promoter region that drives Ecol\lacZ expression, the insertion point is 257 nucleotides upstream of the most distal initiation start site.

(Hama et al., 1990)

Insertion of a P-element transposon into the en gene. The transposon carries the Ecol\lacZ gene under the control of an en promoter.

(Williams et al., 1990)

Insertion of Ecol\lacZ^en-Xho25 into en.

(Simcox et al., 1989)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with en^Adv-1)

(Srivastava et al., 2002)

lethal | recessive

(Maschat et al., 1998, Locke and Hanna, 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

Heterozygotes with Df(2R)en-SFX31 fail to survive. Homozygotes occasionally survive and display wing defects.

(Hama et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

en^Xho25, ph-p^lac has visible | dominant phenotype

(Maschat et al., 1998)

en^Xho25, ph-p⁴¹⁰ has visible | dominant phenotype

(Maschat et al., 1998)

en^Xho25, ph-p⁴¹⁰ has visible phenotype

(Maschat et al., 1998)

en^Xho25, ph-p^lac has visible | recessive phenotype

(Maschat et al., 1998)

Phenotype Manifest In

Other

Statement

Reference

en^Xho25, ph-p^lac has wing vein L4 phenotype

(Maschat et al., 1998)

en^Xho25, ph-p⁴¹⁰ has wing vein L4 phenotype

(Maschat et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

80% of ph-p⁴¹⁰/Y; en^Xho25/+ double heterozygotes have a gap in the fourth wing vein at 25^oC. 20% of ph-p^lac/Y ; en^Xho25/+ flies have a gap in the fourth wing vein at 25^oC.

(Maschat et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

en^nst-101

(Bhojwani et al., 1995)

en^nst-120

(Bhojwani et al., 1995)

Comments

Images (0)