FlyBase Allele Report: Dmel\fng[80]

General Information

Symbol

Dmel\fng⁸⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0034617

Feature type

allele

Associated gene

Dmel\fng

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Fleming et al., 1997, Irvine and Wieschaus, 1994)

Mutagen

Delta2-3 transposase

(Irvine and Wieschaus, 1994)

Progenitor genotype

fng¹

(Irvine and Wieschaus, 1994)

Cytology

Description

Deletion removing P element and approximately 10kb of flanking DNA.

(Irvine and Wieschaus, 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Cho and Choi, 1998)

lethal (with fng¹)

(Correia et al., 2003)

lethal (with fng³)

(Correia et al., 2003)

lethal (with fng⁵)

(Correia et al., 2003)

lethal (with fng⁷)

(Correia et al., 2003)

lethal (with fng⁸)

(Correia et al., 2003)

lethal (with fng¹¹)

(Correia et al., 2003)

lethal (with fng¹³)

(Correia et al., 2003)

lethal (with fng¹⁴)

(Correia et al., 2003)

lethal (with fng¹²⁹)

(Correia et al., 2003)

lethal (with fng^L19)

(Correia et al., 2003)

lethal (with fng^L73)

(Correia et al., 2003)

lethal (with fng^L81)

(Correia et al., 2003)

lethal (with fng^L83)

(Correia et al., 2003)

lethal | recessive

(Irvine and Wieschaus, 1994)

lethal - all die before end of larval stage | recessive

(Fleming et al., 1997)

partially lethal - majority live (with fng²)

(Correia et al., 2003)

partially lethal - majority live (with fng⁵²)

(Correia et al., 2003)

partially lethal - majority live (with fng^M69)

(Correia et al., 2003)

some die during larval stage | recessive

(Fleming et al., 1997)

Phenotype Manifest In

denticle | ectopic

(Walters et al., 2005)

follicle cell (with fng²)

(Grammont and Irvine, 2001)

ommatidium

(Cho and Choi, 1998)

ovary (with fng²)

(Grammont and Irvine, 2001)

photoreceptor

(Cho and Choi, 1998)

stalk follicle cell (with fng²)

(Grammont and Irvine, 2001)

wing

(Irvine and Wieschaus, 1994)

wing (with fng²)

(Correia et al., 2003)

wing (with fng⁵²)

(Correia et al., 2003)

wing (with fng^M69)

(Correia et al., 2003)

wing vein

(Irvine and Wieschaus, 1994)

wing vein | ectopic

(Irvine and Wieschaus, 1994)

Detailed Description

Statement

Reference

fng⁸⁰/+ flies have normal wings.

(Bronstein et al., 2010)

fng⁸⁰ mutants have extra denticles on the abdomen. These denticles lack orientation and are interspersed with the normally-formed denticle rows 2-4.

(Walters et al., 2005)

Transheterozygous fng²/fng⁸⁰ females have ovaries showing 0% compound follicles, 26% with long stalks 48% of follicles have abnormal epithelium. The long stalk phenotype is sometimes accompanied by a stalk disorganization phenotype.

(Grammont and Irvine, 2001)

Mutant clones induced in the equator or dorsal region of the developing eye do not show significant polarity changes either inside or outside the clone boundary. Mutant clones induced in the ventral domain (close to or far from the equator) caused polarity reversals extending up to four ommatidia from the clone boundary. The shift in chirality is observed only outside the clone boundaries towards the normal equator. Photoreceptor numbers are affected in 24% of ommatidia.

(Cho and Choi, 1998)

fng⁸⁰/fng⁵² mutants are weakly viable and exhibit a severe wing margin loss phenotype.

(Fleming et al., 1997)

Mutant clones in the wing reveal ectopic wing margins along clone borders, composed of both wild type and mutant cells. Ectopic margins are composed of a mirror image duplication of dorsal-type bristles. Clone boundaries farther from the normal margin often partially or completely fail to induce ectopic margins. Clones contained with the dorsal surface can be associated with an expansion of the dorsal wing surface. The size of distal outgrowths varies with their location in the wing. Some clones are associated with loss of tissue from the wing margin and reduction in size of the wing. fng⁺ is not autonomously required for wing cell viability.

(Irvine and Wieschaus, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

fng[+]/fng⁸⁰ is an enhancer of visible | dominant phenotype of Bx¹

(Bejarano et al., 2008, Milan et al., 2004)

fng⁸⁰ is an enhancer of visible | dominant phenotype of Bx¹

(Milan et al., 1998)

Phenotype Manifest In

Suppressed by

Statement

Reference

fng⁸⁰ has denticle | ectopic phenotype, suppressible by Ser^RX82

(Walters et al., 2005)

Enhancer of

Statement

Reference

fng[+]/fng⁸⁰ is an enhancer of wing margin phenotype of Bx²

(Bronstein et al., 2010)

fng[+]/fng⁸⁰ is an enhancer of wing margin phenotype of Bx¹

(Bejarano et al., 2008, Milan et al., 2004)

fng⁸⁰ is an enhancer of wing phenotype of Bx¹

(Milan et al., 1998)

NOT Suppressor of

Statement

Reference

fng⁸⁰ is a non-suppressor of denticle row 3 phenotype of Ser^RX82

(Walters et al., 2005)

fng⁸⁰ is a non-suppressor of denticle row 4 phenotype of Ser^RX82

(Walters et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Ser^RX82, fng⁸⁰ double mutants show the same denticle row phenotype as Ser^RX82 single mutants, in which a denticle row is missing.

(Walters et al., 2005)

The severity of the Bx¹/+ wing scalloping phenotype is enhanced by one copy of fng⁸⁰.

(Milan et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

fng²

(Grammont and Irvine, 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

One of 28 lethal alleles recovered from fng¹.

(Irvine and Wieschaus, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

fng⁸⁰

(Bronstein et al., 2010, Bejarano et al., 2008, Thomas and van Meyel, 2007, Walters et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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