FB2024_03 , released June 25, 2024
Allele: Dmel\boca1
Open Close
General Information
Symbol
Dmel\boca1
Species
D. melanogaster
Name
FlyBase ID
FBal0035058
Feature type
allele
Associated gene
Dmel\boca
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Roote, 1995.9.26, Heitzler et al., 1993)
Progenitor genotype
Cytology
Description

Amino acid replacement: W49R. Nucleotide substitution: T?A.

(Culi and Mann, 2003)

A point mutation inside the ORF.

(Culi, 2002.3.22)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:7,566,518..7,566,518 [-]
Nucleotide change:

T7566518A

Reported nucleotide change:

T?A

Amino acid change:

W49R | boca-PA

Reported amino acid change:

W49R

(Culi and Mann, 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When homozygous clones are made in adults, a cell-autonomous loss of sensory bristles along the wing margin and a non-autonomous induction of wing margin bristles next to the clone is seen. In clones in the notum a loss of dorsoventral bristles can be seen. Ectopic eyes are also seen in clones in the dorsal head. Homozygous wing discs have no wing pouch and have a mirror image duplication of the presumptive notum and hinge regions. Homozygous leg discs are comprised entirely of cells with a proximal identity. Mosaic females with a boca1 germline lay eggs that have a yolkless phenotype.

      (Culi and Mann, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      boca1 is partially rescued by bocaUAS.cCa/Scer\GAL4Act5C.PP

      (Culi and Mann, 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ew23
      (Roote, 1995.9.26)
      boca1
      (Kahsai and Cook, 2018, Khaliullina et al., 2009)
      l(2)43Ea1
      (Heitzler et al., 1993)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)