FlyBase Allele Report: Dmel\Raf::tor[12D.hs.sev]

General Information

Symbol

Dmel\Raf::tor^12D.hs.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0035391

Feature type

allele

Associated gene

Raf::tor

Associated Insertion(s)

Carried in Construct

P{sE-raf^torY9}

Also Known As

sE-raf^torY9, Raf^torY9, Raf^tor9

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Brunner et al., 1994)

Progenitor genotype

Carried in construct

P{sE-raf^torY9}

Cytology

Description

Activated Raf::tor construct with same amino acid replacement in tor segment as for tor^12D, whose expression is governed by a sev enhancer and Hsp70 promoter.

(Brunner et al., 1994)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

sev

Encoded product / tool

Raf::tor

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Vidal et al., 2005, Luschnig et al., 2000)

visible | dominant

(van der Straten et al., 1997, Dickson et al., 1995)

Phenotype Manifest In

cone cell

(Dickson et al., 1995)

eye

(Vidal et al., 2005, Luschnig et al., 2000, Dickson et al., 1996, Zeidler et al., 1996, Brunner et al., 1994)

ommatidium

(Luschnig et al., 2000, Biggs et al., 1994)

photoreceptor cell R7

(Dickson et al., 1996)

photoreceptor cell R7 | ectopic

(van der Straten et al., 1997, Brunner et al., 1994)

photoreceptor neuron

(Hou et al., 1997)

Detailed Description

Statement

Reference

Flies carrying phl::tor^12D.hs.sev have a rough eye phenotype.

(Luschnig et al., 2000)

Adults exhibit a rough eye phenotype that cannot be suppressed by heterozygosity for Jra (Jra^76-19).

(Hou et al., 1997)

Homozygous 14-3-3ζ^E16 clones are recovered in flies carrying phl::tor^12D.hs.sev, but not in a wild-type background.

(Kockel et al., 1997)

Rough eye phenotype due to the recruitment of multiple R7 photoreceptor cells.

(van der Straten et al., 1997)

Rough eye phenotype.

(Dickson et al., 1996, Biggs et al., 1994)

Rough eye phenotype is slightly suppressed by Jra^{bZIP.hs.sev.T:Ivir\HA1}.

(Bohmann et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Raf::tor^12D.hs.sev has eye phenotype, enhanceable by S^2J1

(Dickson et al., 1996)

NOT Enhanced by

Statement

Reference

Raf::tor^12D.hs.sev has phenotype, non-enhanceable by Shc^111-40

(Luschnig et al., 2000)

Raf::tor^12D.hs.sev has phenotype, non-enhanceable by Shc^BG

(Luschnig et al., 2000)

Suppressed by

Statement

Reference

Raf::tor^12D.hs.sev has phenotype, suppressible by lilli^XS407

(Tang et al., 2001)

Raf::tor^12D.hs.sev has phenotype, suppressible by lilli^s35

(Tang et al., 2001)

Raf::tor^12D.hs.sev has phenotype, suppressible by lilli^XS575

(Tang et al., 2001)

Raf::tor^12D.hs.sev has photoreceptor cell R7 | ectopic phenotype, suppressible by Hsp83[+]/Hsp83^13F3

(van der Straten et al., 1997)

Raf::tor^12D.hs.sev has photoreceptor cell R7 | ectopic phenotype, suppressible by Hsp83^9J1/Hsp83[+]

(van der Straten et al., 1997)

Raf::tor^12D.hs.sev has eye phenotype, suppressible by rl^4H6

(Dickson et al., 1996)

Raf::tor^12D.hs.sev has eye phenotype, suppressible by rl^6L1

(Dickson et al., 1996)

Raf::tor^12D.hs.sev has eye phenotype, suppressible by rl^8M4

(Dickson et al., 1996)

Raf::tor^12D.hs.sev has eye phenotype, suppressible by lilli^3E8

(Dickson et al., 1996)

Raf::tor^12D.hs.sev has eye phenotype, suppressible by lilli^4P5

(Dickson et al., 1996)

Raf::tor^12D.hs.sev has eye phenotype, suppressible by lilli^4U5

(Dickson et al., 1996)

Raf::tor^12D.hs.sev has eye phenotype, suppressible by lilli^5J1

(Dickson et al., 1996)

Raf::tor^12D.hs.sev has eye phenotype, suppressible by lilli^5X5

(Dickson et al., 1996)

Raf::tor^12D.hs.sev has eye phenotype, suppressible by phyl¹

(Dickson et al., 1996)

Raf::tor^12D.hs.sev has eye phenotype, suppressible by rl^2L1

(Dickson et al., 1996)

Raf::tor^12D.hs.sev has eye phenotype, suppressible by rl^2M1

(Dickson et al., 1996)

Raf::tor^12D.hs.sev has eye phenotype, suppressible by TfIIA-S^E73

(Zeidler et al., 1996)

Raf::tor^12D.hs.sev has phenotype, suppressible by phyl^+t15

(Dickson et al., 1995)

Raf::tor^12D.hs.sev has photoreceptor cell R7 phenotype, suppressible by phyl¹

(Dickson et al., 1995)

Raf::tor^12D.hs.sev has photoreceptor cell R7 phenotype, suppressible by phyl²

(Dickson et al., 1995)

Raf::tor^12D.hs.sev has photoreceptor cell R7 phenotype, suppressible by phyl³

(Dickson et al., 1995)

Raf::tor^12D.hs.sev has photoreceptor cell R7 phenotype, suppressible by phyl⁴

(Dickson et al., 1995)

Raf::tor^12D.hs.sev has photoreceptor cell R7 phenotype, suppressible by phyl⁵

(Dickson et al., 1995)

Raf::tor^12D.hs.sev has photoreceptor cell R7 phenotype, suppressible by phyl⁶

(Dickson et al., 1995)

Raf::tor^12D.hs.sev has phenotype, suppressible by rl[+]/rl^2L1

(Biggs et al., 1994)

Raf::tor^12D.hs.sev has phenotype, suppressible by rl[+]/rl^2M1

(Biggs et al., 1994)

Raf::tor^12D.hs.sev has ommatidium phenotype, suppressible by rl[+]/rl^4H6

(Biggs et al., 1994)

Raf::tor^12D.hs.sev has photoreceptor cell R7 | ectopic phenotype, suppressible by Df(2R)rl10a/+

(Brunner et al., 1994)

NOT suppressed by

Statement

Reference

Raf::tor^12D.hs.sev has phenotype, non-suppressible by Shc^111-40

(Luschnig et al., 2000)

Raf::tor^12D.hs.sev has phenotype, non-suppressible by Shc^BG

(Luschnig et al., 2000)

Enhancer of

Statement

Reference

Raf::tor^12D.hs.sev is an enhancer of phenotype of svp^1.sev

(Begemann et al., 1995)

Raf::tor^12D.hs.sev is an enhancer of phenotype of svp^2.sev

(Begemann et al., 1995)

Other

Statement

Reference

Df(2R)rl10a/+, Raf::tor^12D.hs.sev has eye phenotype

(Brunner et al., 1994)

Df(2R)rl10a/+, Raf::tor^12D.hs.sev has photoreceptor cell R7 phenotype

(Brunner et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Removal of one copy of Hsp83 prevents the recruitment of additional R7 cells caused by phl::tor^12D.hs.sev, reverting the phenotype to almost wild type and introduction of Hsp83^+t7.5 or Hsp83^hs.2sev results in the reappearance of additional R7 cells. Hsp83^e6D interact genetically with the phl::tor^12D.hs.sev, other E(sev) Hsp83 mutations fail to interact.

(van der Straten et al., 1997)

Eye phenotype enhanced by alleles of S. Eye phenotype suppressed by alleles of lilli, rl and phyl.

(Dickson et al., 1996)

TfIIA-S^E73 suppresses the rough eye phenotype of sev^{S11.T:Hsap\MYC}, phl::tor^12D.hs.sev, Ras85D^V12.sev, rl^Sem and svp^2.sev.

(Zeidler et al., 1996)

Enhancer of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

(Begemann et al., 1995)

Rough eye phenotype of phl::tor^12D.hs.sev is almost completely eliminated by phyl mutants.

(Dickson et al., 1995)

The recruitment of multiple R7 cells caused by phl::tor^12D.hs.sev is suppressed in phl::tor^12D.hs.sev; Df(2R)rl10a/+ flies, which have smooth eyes with a greatly reduced number of R7 cells.

(Brunner et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (7)

Bloomington

5808