FlyBase Allele Report: Dmel\pk[pk-sple-14]

General Information

Symbol

Dmel\pk^pk-sple-14

Species

D. melanogaster

Name

FlyBase ID

FBal0035401

Feature type

allele

Associated gene

Dmel\pk

Associated Insertion(s)

Carried in Construct

Also Known As

pk^pk-sple14

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Gubb et al., 1999, Heitzler et al., 1993)

Progenitor genotype

Cytology

Description

Lesion present between 41.3 and 48.6kb downstream of zero (zero being 973bp proximal to the pk transcription start site.).

(Gubb et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Gubb et al., 1999, Heitzler et al., 1993)

abnormal visual behavior

(Heitzler et al., 1993)

visible | recessive

(Gubb et al., 1999)

Phenotype Manifest In

abdomen

(Gubb et al., 1999)

eye

(Gubb et al., 1999, Heitzler et al., 1993)

leg

(Gubb et al., 1999)

leg & macrochaeta

(Heitzler et al., 1993)

leg & trichome

(Heitzler et al., 1993)

mesothoracic tergum & sensory mother cell & spindle

(Bellaiche et al., 2004)

scutum

(Gubb et al., 1999)

wing

(Gubb et al., 1999)

wing blade dorsal compartment

(Doyle et al., 2008)

wing hair

(Doyle et al., 2008, Heitzler et al., 1993)

Detailed Description

Statement

Reference

In contrast to wild-types, no clear wing membrane ridge orientation is apparent in either the anterior or posterior region of the wing of pk^pk-sple-14 mutants.

Wing hairs of pk^pk-sple-14 mutants display moderate polarity defects across the wing.

(Doyle et al., 2008)

In pk^pk-sple-14 mutant pupae, the mitotic spindles of dividing sensory organ precursor cells in the developing notum are not aligned with the anterior-posterior axis, but instead are randomly oriented.

(Bellaiche et al., 2004)

Causes no embryonic phenotype even when homozygous mutant embryos develop from homozygous mutant mothers. Has a weak polarity phenotype in the wing, notum, abdomen, eye and legs. Denticle belt morphology and denticle orientation remains wild-type.

(Gubb et al., 1999)

Rough eyes and weak pk and spiny leg phenotypes.

(Heitzler et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

pk[+]/pk^pk-sple-14 is a non-enhancer of partially lethal phenotype of Nab2^ex3

(Lee et al., 2020)

pk[+]/pk^pk-sple-14 is a non-enhancer of some die during P-stage phenotype of Nab2^ex3

(Lee et al., 2020)

Suppressor of

Statement

Reference

pk[+]/pk^pk-sple-14 is a suppressor | partially of decreased size | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

pk[+]/pk^pk-sple-14 is a suppressor | partially of visible | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

NOT Suppressor of

Statement

Reference

pk[+]/pk^pk-sple-14 is a non-suppressor of partially lethal phenotype of Nab2^ex3

(Lee et al., 2020)

pk[+]/pk^pk-sple-14 is a non-suppressor of some die during P-stage phenotype of Nab2^ex3

(Lee et al., 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

pk[+]/pk^pk-sple-14 is a suppressor | partially of eye phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

pk-sple¹⁴

(Heitzler et al., 1993)

pk¹⁴

pk^pk-sple-14

pk^pk-sple14

(Cho et al., 2022, Cho et al., 2020, Lee et al., 2020, Doyle et al., 2008, Bellaiche et al., 2004)

sple¹⁴

Name Synonyms

Secondary FlyBase IDs

FBal0035669

References (7)

Report Sections

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