FB2024_03 , released June 25, 2024
Allele: Dmel\scra8
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General Information
Symbol
Dmel\scra8
Species
D. melanogaster
Name
FlyBase ID
FBal0035550
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
scraps8
Key Links
Mutagen
Nature of the Allele
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant embryos have cytokinesis defects in the epidermis, but there are no significant defects in muscle pattern.

The lateral chordotonal 5 (Lch5) neurons of scrak08255/scra8 embryos are shifted dorsally, disorganised and enlarged compared to wild type. There is an increase in the amount of DNA within the enlarged Lch5 neurons, indicative of multinucleate cells. There is a loss of Lch5 ligament cells in the mutant embryos, with the mutant embryos having an average of two ligament cells per Lch5 cluster (compared to five in wild-type embryos). The cap cells are present in normal number and orientation in the mutant Lch5 clusters.

scrak08255/scra8 embryos show a drastic decrease in the number of scolopale/sheath cells throughout the peripheral nervous system. The lack of scolopale cells is particularly evident in the Ch lineages, with the five neurons of the Lch5 clusters often having no associated scolopale. No sheath cells are detectable in the ventral' abdominal compartment of the mutant embryos (three sheath cells are seen in this region in wild-type embryos). The number of external sensory (ES) neurons in the ventral' region is reduced compared to wild type. ES organs of the lateral region tend not to lose sheath cells.

The ventral multidendritic neurons are unchanged in number in scrak08255/scra8 embryos, but they are increased in size. There is no reduction in the number of ventral ES structural cells.

scrak08255/scra8 embryos show no difference in the levels of apoptosis compared to controls from stage 10 until the end of embryogenesis.

scrak08255/scra8 embryos have relatively higher numbers of mitotic cells than wild-type embryos by the end of stage 12. This phenotype becomes more striking during the latter stages of embryonic development. Mitotic bodies are seen within differentiated peripheral nervous system neurons.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhancer of
Statement
Reference

scra[+]/scra8 is a non-enhancer of mitotic domain 1 | embryonic cycle 14 phenotype of CycB+t10

NOT Suppressor of
Statement
Reference

scra[+]/scra8 is a non-suppressor of mitotic domain 1 | embryonic cycle 14 phenotype of CycB+t10

scra8 is a non-suppressor of phenotype of arm3

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)