FlyBase Allele Report: Dmel\Dsor1[r1]

General Information

Symbol

Dmel\Dsor1^r1

Species

D. melanogaster

Name

FlyBase ID

FBal0039036

Feature type

allele

Associated gene

Dmel\Dsor1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Tsuda et al., 1993)

Progenitor genotype

Dsor1^Su1

(Tsuda et al., 1993)

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased occurrence of cell division | embryonic stage | somatic clone

(Tsuda et al., 1993)

decreased occurrence of cell division | larval stage | somatic clone

(Lim et al., 1999)

lethal | recessive

(Holland et al., 1997, Tsuda et al., 1993)

Phenotype Manifest In

imaginal disc | larval stage | somatic clone

(Lim et al., 1999)

Detailed Description

Statement

Reference

Clonal analysis indicates that the rate of proliferation in imaginal discs is reduced to approximately 63% of wild type in homozygous clones.

(Lim et al., 1999)

Twin spot analysis demonstrates a reduction of the proliferation rate. Anterior and posterior structures are defective in some embryos derived from homozygous germ line clones, others exhibit poor cuticle development.

(Tsuda et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Dsor1^r1 has decreased occurrence of cell division | somatic clone | larval stage phenotype, suppressible by rl^Su23/rl[+]

(Lim et al., 1999)

NOT suppressed by

Statement

Reference

Dsor1^r1 has lethal | recessive phenotype, non-suppressible by hep^Ubi-p63E.PG

(Holland et al., 1997)

Dsor1^r1 has lethal | recessive phenotype, non-suppressible by Mmus\Map2k7^Ubi-p63E.PH

(Holland et al., 1997)

Dsor1^r1 has lethal | recessive phenotype, non-suppressible by Mmmm\Sek1^Ubi-p63E.PH

(Holland et al., 1997)

Dsor1^r1 has lethal | recessive phenotype, non-suppressible by Xlae\Mek2^Ubi-p63E.PH

(Holland et al., 1997)

Other

Statement

Reference

Dsor1^r1, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Dsor1[+]/Dsor1^r1, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Phenotype Manifest In

Suppressed by

Statement

Reference

Dsor1^r1 has imaginal disc | somatic clone | larval stage phenotype, suppressible by rl^Su23/rl[+]

(Lim et al., 1999)

Enhancer of

Statement

Reference

Dsor1^r1/Scer\GAL4^Bx-MS1096 is an enhancer of wing phenotype of Bant\lef^UAS.cGa

(Guichard et al., 2006)

Dsor1^r1/Scer\GAL4^Bx-MS1096 is an enhancer of wing vein phenotype of Bant\lef^UAS.cGa

(Guichard et al., 2006)

Suppressor of

Statement

Reference

Dsor1^r1 is a suppressor of embryonic/first instar larval cuticle | maternal effect phenotype of tor^12D

(Li and Li, 2003)

Dsor1^r1 is a suppressor of phenotype of Src42A^KR.hs.2sev

(Takahashi et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

The imaginal disc proliferation defect is suppressed by rl^Su23/+.

(Lim et al., 1999)

The lethality of hemizygous males is not rescued by hep^Ubi-p63E.PG.

(Holland et al., 1997)

Xenogenetic Interactions

Statement

Reference

Moderate expression of Zzzz\lef^Scer\UAS.cGa under the control of Scer\GAL4^Bx-MS1096 in Dsor1^r1 results in an aggravated Zzzz\lef^Scer\UAS.cGa (Scer\GAL4^Bx-MS1096) phenotype consisting of more pronounced scooped wings and distal vein truncations.

(Guichard et al., 2006)

The lethality of hemizygous males is not rescued by Mmus\Prkmk7^Ubi-p63E.PH, Mmmm\Sek1^Ubi-p63E.PH or Xlae\Mek2^Ubi-p63E.PH.

(Holland et al., 1997)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Lost the suppressing activity of Dsor1^Su1.

(Tsuda et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

D-mek^r1

(Hsu and Perrimon, 1994)

Dsor1^r1

(Guichard et al., 2006)

Dsor^r1

(Li et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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