FlyBase Allele Report: Dmel\Su(var)3-9[17]

General Information

Symbol

Dmel\Su(var)3-9¹⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0039075

Feature type

allele

Associated gene

Dmel\Su(var)3-9

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

loss of function allele

(Ebert et al., 2004)

Mutagen

X ray

(Tschiersch et al., 1994)

Progenitor genotype

Cytology

Description

Deletion of 8bp within the open reading frame of a 2.4kb transcript.

(Tschiersch et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Delta^UAS.cDa, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

suppressor of variegation | dominant, with In(1)w^m4h

(Tschiersch et al., 1994)

Phenotype Manifest In

Detailed Description

Statement

Reference

No abdominal dorsal fusion defects are seen in Su(var)3-9¹⁷ males.

(Gibert et al., 2011)

Strong suppressors of bw and w position effect variegation (PEV).

(Tschiersch et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Su(var)3-9¹⁷ has suppressor of variegation phenotype, suppressible by Hsap\SUV39H1^hs.EGFP

(Schotta et al., 2002)

Enhancer of

Statement

Reference

Su(var)3-9¹⁷ is an enhancer of visible | adult stage | temperature conditional phenotype of crm³²

(Gibert et al., 2011)

Suppressor of

Statement

Reference

Su(var)3-9¹⁷ is a suppressor of visible | adult stage | temperature conditional phenotype of crm³²

(Gibert et al., 2011)

Su(var)3-9[+]/Su(var)3-9¹⁷ is a suppressor of neoplasia phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

Su(var)3-9[+]/Su(var)3-9¹⁷ is a suppressor of visible phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

Phenotype Manifest In

Enhancer of

Statement

Reference

Su(var)3-9¹⁷ is an enhancer of adult abdomen | temperature conditional phenotype of crm³²

(Gibert et al., 2011)

Suppressor of

Statement

Reference

Su(var)3-9¹⁷ is a suppressor of sex comb | increased number | temperature conditional phenotype of crm³²

(Gibert et al., 2011)

Su(var)3-9[+]/Su(var)3-9¹⁷ is a suppressor of eye phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

Other

Statement

Reference

Su(var)3-9¹⁷, egg^G19561 has ovary phenotype

(Yoon et al., 2008)

Su(var)3-9¹⁷, egg^G19561 has egg chamber phenotype

(Yoon et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Su(var)3-9¹⁷ enhances the abdominal dorsal fusion defects seen in crm³² mutants; unlike in crm³² alone, dorsal fusion phenotypes are visible at 25[o]C. In contrast the crm³² ectopic sex comb phenotype is suppressed.

(Gibert et al., 2011)

egg^G19561; Su(var)3-9¹⁷ double mutants mostly exhibit a gourd-shaped germaria and defects in the budding off of new egg chambers; as a result, the double mutant has no developing egg chambers in the ovary.

(Yoon et al., 2008)

Su(var)3-9¹⁷ dominantly suppresses the eye tumour phenotype of flies expressing Dl^Scer\UAS.cDa under the control of Scer\GAL4^ey.PH and also carrying the P{GSV1}lola^GS88A8 insertion (which results in the lola^GS88A8 and psq^GS88A8 alleles being expressed under the control of Scer\GAL4^ey.PH).

(Ferres-Marco et al., 2006)

Has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males.

(McKee et al., 2000)

Xenogenetic Interactions

Statement

Reference

The addition of Hsap\SUV39H^{hs.T:Avic\GFP-EGFP} partially complements the suppression of PEV phenotype seen in Su(var)3-9¹⁷ animals.

(Schotta et al., 2002)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ290956

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

3-9¹⁷

(McKee et al., 2000)

Su(var)3-917

(Silva-Sousa and Casacuberta, 2013)

Su(var)3-9¹⁷

(Seller et al., 2019, Colmenares et al., 2017, Xing and Li, 2015, Gibert et al., 2011, Yoon et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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