FB2024_03 , released June 25, 2024
Allele: Dmel\aosp2
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General Information
Symbol
Dmel\aosp2
Species
D. melanogaster
Name
FlyBase ID
FBal0039374
Feature type
allele
Associated gene
Dmel\aos
Associated Insertion(s)
P{lacW}aosp2
Carried in Construct
Also Known As
argossty2, aos-lacZ
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Okabe et al., 1996, Okano et al., 1992)
Progenitor genotype
Associated Insertion(s)
P{lacW}aosp2
Cytology
Description

P-element insertion within the transcription unit.

(Okano et al., 1992)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes exhibit failure of head involution.

      (Okabe et al., 1996)

      Retinal axons fail to spread in the characteristic half moon shape after extending through the optic stalk. This phenotype can be rescued by argoshs.PSb. Numbers of laminal glial cells are reduced, and the neuropiles in optic lobes show an irregular morphology, though penetrance is variable.

      (Sawamoto et al., 1996)

      Rough eye phenotype. Homozygous eyes have extra neural cells that develop into supernumerary photoreceptor cells, the organisation of rhabdomeres is severely disrupted and the arrangement of R1-R6 cells can be clockwise or anticlockwise. External eye shows fusion of several lenses and a disruption in the numbering and spacing of bristles. Laminar structure of the optic lobe is disrupted. Heterozygotes with Df(3L)st-f13 or Df(3L)st-j7 have defective wings and eyes. Heterozygotes with Df(3L)st-k10 show a slightly rough eye phenotype. Heterozygotes with Df(3L)st4 are lethal and exhibit failure of head involution, failure germ band retraction.

      (Okano et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      aosp2 is rescued by aoshs.PSa

      (Sawamoto et al., 1996)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the P-element results in reversion of the mutant phenotype to wild type.

      (Okano et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      aosp2
      argosp2
      argossty2
      (Shamloula et al., 2002, Okabe et al., 1996, Sawamoto et al., 1996)
      gilp2
      styP2
      styp2
      (Okano et al., 1992)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)