FB2024_03 , released June 25, 2024
Allele: Dmel\tsr1
Open Close
General Information
Symbol
Dmel\tsr1
Species
D. melanogaster
Name
FlyBase ID
FBal0044408
Feature type
allele
Associated gene
Dmel\tsr
Associated Insertion(s)
P{A92}tsr1
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{A92}tsr1
Cytology
Description

Insertion of a P{A92} element in the 5' untranslated region of tsr.

(Gunsalus et al., 1995)
Allele components
Component
Use(s)
Inserted element
P{A92}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Terminal filaments are present in the larval ovary of tsr1 homozygotes and tsr1/tsr2 animals. tsr1/tsrntf animals are semi-viable at 25oC; only males survive and are sterile. At 18oC, these animals are viable and some males are fertile, while females are sterile and show defects in border cell migration. The border cell migration defects are more severe at higher temperatures. Some egg chambers show "dumping" of nurse cell nuclei into the oocyte at 25oC. Terminal filaments are present in the larval ovary of tsr1/tsrntf animals.

      (Chen et al., 2001)

      At early stages of oogenesis actin filaments are seen in clumps throughout the tsr mutant egg chamber.

      (Baum et al., 2000)

      Mutant spermatid cysts contain two types of ring canals (RCs); normally-sized RCs and RCs that are smaller than wild type (23% of total). The fusome reforms in mutant spermatid cysts but it is often interrupted and fails to connect all the extant RCs.

      (Giansanti et al., 1999)

      Homozygotes die at the larval/pupal transition.

      (Giansanti et al., 1998)

      A significant proportion of homozygous and tsr1/tsr2 larval neuroblasts are polyploid. The mitotic index and number of mitotic cells in anaphase is nearly normal, and chromosomes appear morphologically normal. The two asters of homozygous primary spermatocytes remain in close proximity to each other at the M1a stage, and do not associate with the nuclear envelope. After the M1 stage, the asters progressively resume a relatively normal position and the spermatocytes appear indistinguishable from wild-type throughout the remainder of the first meiotic division. Prophase/prometaphase secondary spermatocytes show the same defect in aster migration and positioning as that seen in the primary spermatocytes at stage M1. The spindles become more normal by metaphase II, and retain a wild-type appearance throughout the remainder of meiosis II. 30% of spermatids contain an abnormal sized Nebenkern and more than one nucleus. The distribution of actin during meiosis is abnormal in spermatocytes.

      (Gunsalus et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      psidin55D4/psidin[+], tsr1/tsrntf has lethal phenotype

      (Kim et al., 2011)

      psidin85D1/psidin[+], tsr1/tsrntf has lethal phenotype

      (Kim et al., 2011)

      psidin[+]/psidine02846, tsr1/tsrntf has lethal phenotype

      (Kim et al., 2011)

      ssh1-63/ssh[+], tsr1/tsrntf has lethal phenotype

      (Kim et al., 2011)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of psidinScer\UAS.cKa under the control of Scer\GAL4slbo.2.6 in a tsr1 heterozygous background has little or no effect on border cell migration.

      (Kim et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The phenotype of tsr1 chicR1 animals indicates that chic is epistatic to tsr.

      (Giansanti et al., 1998)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tsr1
      (Das et al., 2016, Kim et al., 2011, Corrigall et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)