FlyBase Allele Report: Dmel\HDAC1[15-1]

General Information

Symbol

Dmel\HDAC1^15-1

Species

D. melanogaster

Name

FlyBase ID

FBal0045042

Feature type

allele

Associated gene

Dmel\HDAC1

Associated Insertion(s)

P{hsneo.ry⁺}HDAC1^15-1

Carried in Construct

Also Known As

rpd3^P-1.8

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(De Rubertis et al., 1996)

Mutagen

P-element activity

(De Rubertis et al., 1996, De Rubertis et al., 1996)

Progenitor genotype

Associated Insertion(s)

P{hsneo.ry⁺}HDAC1^15-1

Cytology

Description

P-element insertion 1.8kb from the 5' end of the transcript in the putative regulatory region.

(De Rubertis et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

enhancer of variegation, with In(1)w^m4

(De Rubertis et al., 1996)

enhancer of variegation | dominant, with In(1)w^m4

(Mottus et al., 2000)

fertile

(Mottus et al., 2000)

suppressor of variegation | recessive, with In(1)w^m4

(Mottus et al., 2000)

viable

(Mottus et al., 2000, De Rubertis et al., 1996)

Phenotype Manifest In

ommatidium

(De Rubertis et al., 1996)

Detailed Description

Statement

Reference

Enhancer of variegation.

(De Rubertis et al., 1996)

Enhances the variegation of w in In(1)w^m4 flies and in 5-10% of the eyes patches of ommatidia show disorganisation characteristic of the rst mutation (enhancement of variegation allows the silencing to spread past the w locus to inactivate rst in a fraction of the cells).

(De Rubertis et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

HDAC1³⁰³

(Mottus et al., 2000)

HDAC1³¹³

(Mottus et al., 2000)

HDAC1³²⁸

(Mottus et al., 2000)

HDAC1³²⁶

(Mottus et al., 2000)

Comments

Transheterozygotes of Rpd3^15-1 with Rpd3³⁰³, Rpd3³¹³, Rpd3³²⁶ or Rpd3³²⁸ are viable and fertile, and show weak to moderate suppression of In(1)w^m4 PEV.

(Mottus et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Excision of the transposon fully reverts the enhancer phenotype.

(De Rubertis et al., 1996)

External Crossreferences and Linkouts ( 2 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

Y09258

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

CAA70455

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Evar15-1

(De Rubertis et al., 1996)

HDAC1^15-1

Rpd3^15-1

rpd3^P-1.8

(Bauer et al., 2004, Rogina et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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